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channel gating is the process of opening and closing ion channels in a cell membrane
true or false?
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- Ion channels, such as the K+ channel, can have open and closed forms that respond to membrane potential. In addition, an amino-terminal domain, called the inactivation domain or inactivation gate, can block the channel. This is called the ball and chain model of channel inactivation. Identify the statements that correctly describe the ball and chain model. The inactivation gate can only inactivate a channel that has closed in response to depolarization. A shorter tether or chain peptide strand attached to the inactivation domain would increase the time required to inactivate the K+ channel. A mutation causing the loss of the inactivation gate in K+ channels could result in a membrane that undergoes repolarization more slowly. After depolarization and channel opening, the inactivation gate soon occludes the open channel.Which statement best describes the interaction that occurs as a result of the binding of a ligand to a ligand-gated ion channel receptor? A B с D ligand extracellular environment gate closed inactive ligand-gated ion channel receptor ions The process permanently opens or closes the ion channel. cytoplasm The process alters the membrane potential by changing the intracellular ionic concentration. The process causes G proteins to bind with GTP and become activated. The process removes three sodium ions from the cell and brings in two potassium ions.Uniporters are protein channels that move one specific substance across a cell membrane. Identify two substances that move through at uniporter protein channel.
- In the above diagram, letter C represents: A voltage-gated K+ channel A leaky Na+ channel A leaky K+ channel A voltage-gated Na+ channelIf a cell with the following ion concentrations had a resting membrane potential of -40mV which of the following can you conclude? Extracellular: Cl- = 110 mM, Na+ = 145 mM, K+ = 5mM. Intracellular Cl- = 20 mM, Na+ = 10 mM, K+ = 140mM a) At rest it is only permeable to potassium b) At rest it has some permeability to more than one of these ions c) At rest it is only permeable to chloride d) Rest it is not permeable to sodiumSeparately, draw a table using arrows to depict the appropriate magnitude and direction of the forces and ion fluxes at different membrane potentials for a ligand-gated channel that is equally permeable to both ion X+ and ion Y+. The equilibrium potential for ion X+ is -60 mV, and the equilibrium potential for ion Y+ is -20 mV. Which item (a, b, c, or d) best represents the forces and fluxes for a membrane potential of +20 mV? Upwards arrows means outward direction and downwards arrow means inward direction. The length of the arrow determines the magnitude.
- Which of the following statements about ion channels is INCORRECT? Like carrier proteins, most channel proteins are specific regarding which molecules are allowed to pass. Channel proteins can have open or closed configurations. Unlike carrier proteins, some channel proteins are engaged in active transport of solutes. Channel proteins are used extensively in nerve cells, in which they are responsible for transduction of electrical signals. Compared to carrier proteins, channel proteins allow much faster transport.Separately, draw a table using arrows to depict the appropriate magnitude and direction of the forces and ion fluxes at different membrane potentials for a ligand-gated channel that is equally permeable to both ion X+ and ion Y+. The equilibrium potential for ion X+ is -60 mV, and the equilibrium potential for ion Y+ is -20 mV. Which item best represents the forces and fluxes for a membrane potential of -60 mV? Pick one of the four tables in the included image please for your answer.Which of the following is the correct statement regarding ion channels? Physical deformation of the membrane cannot open ion channels Ligand-gating means that an ion binds to the channel, which stimulates its opening. If the channel pore was the right size, Na and K could both pass through because they have the same charge A voltage gated Na channel can open to allow Na movement against its electrochemical gradient
- There are two types of gated ion channels. Name the 2 types and provide a description of how they workSeparately, draw a table using arrows to depict the appropriate magnitude and direction of the forces and ion fluxes at different membrane potentials for a ligand-gated channel that is equally permeable to both ion X+ and ion Y+. The equilibrium potential for ion X+ is -60 mV, and the equilibrium potential for ion Y+ is -20 mV. Which item best represents the forces and fluxes for a membrane potential of 0 mV?Let's say you have neurons in a petrie dish bath in a solution in which the extracellular K+ concentration is 5 mM and the intracellular concentration is 100 mM. Now you flood the dish with a solution containing K+ at 115 mM. What will be the Equilibrium Potential now for the cell (rounded up to the next integer)? O O mv O 4 mv O 70 mv O -70 mv