Caffeine inhibits feeding activity in tobacco hornworm larvae by inhibiting phosphodiesterase (PDE) increasing cAMP both inhibiting phosphodiesterase (PDE) and increasing cAMP
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- Write the structure of each nucleotide-linked sugar in the pathway shown in FigureA female neonate did well until approximately 24 hours of age when she became lethargic. A sepsis workup proved negative. At 56 hours, she started showing focal seizure activity. The plasma ammonia level was found to be 1,100 μmol/L (normal 5–35 μmol/L). Quantitative plasma amino acid levels revealed a marked elevation of argininosuccinate.19.3 Which one of the following enzymic activities is most likely to be deficient in this patient? EXPLAIN your answerA. Arginase.B. Argininosuccinate lyase.C. Argininosuccinate synthase.D. Carbamoyl phosphate synthetase I.E. Ornithine transcarbamoylase.Panthothenic acid is involved in the metabolic pathways as coenzyme:
- One treatment for hyperuricemia is administration of xanthine oxidase inhibitors like allopurinol. Discuss the mechanism and show an illustration how this drug able to alleviate symptoms of hyperuricemia.Write a balanced equation for the hydrolysis of cGMP, catalyzed by cGMP phosphodiesterase. Would you expect an inhibitor of this enzyme to potentiate or antagonize the action of Viagra? Explain.Provide a diagram of the EPH RECEPTOR B2 (EPHB2) structure. Give annotations of binding sites and enzyme active sites.
- Why is salbutamol better than isoproterenol in asthma management in terms of their binding sites?Write a balanced equation for the hydrolysis of cyclic GMP, catalyzed by CGMP phosphodiesterase. Would you expect an inhibitor of this enzyme to potentiate or antagonize the action of Viagra? Explain.Regarding the mechanism of action of chymotrypsin, the formation of a strong hydrogen bond with the hydroxyl group (serine amino acid) increase its: Basicity Nucleophilicity All the answers are correct Electron density
