Below is a pedigree 3 III 4 5. 6. 7 8 OOO O 4 5 6 7 8 9 IV Inheritance of the disease by the II-3 male from his father rules out what type of inheritance. Explain your reasoning.

Describe sex-linked inheritance, and give a clinical example of this type of inheritance.

Explain the meaning of trisomy 21.

State the chromosomal theory of inheritance and explain the effect of linked genes on chromosomal inheritance

I am having trouble solving this problem sets about sex-linked inheritance. Hemophilia is a recessive X linked genetic disorder (refer to BIOL 40 B), a medical condition in which the ability of the blood to clot is severely reduced, causing the sufferer to bleed severely from even a slight injury. The condition is typically caused by a hereditary lack of a coagulation factor, most often factor VIII or factor IX (refer to Bio 40 B Textbook chapter 19 on Blood). Based on a recent study that used data collected on patients receiving care in federally funded hemophilia treatment centers during the period 2012-2018, as many as 33,000 males in the United States are living with the disorder. Males inherit the X chromosome from their mothers and the Y chromosome from their fathers. Females inherit one X chromosome from each parent. Thus, males can have a disease like hemophilia if they inherit an affected X chromosome that has a mutation in either the factor VIII or factor IX gene. Females can…

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