Below is a figure from a 2015 paper that characterizes the effect of venom from the spider Selenocosmia hainana on voltage-gated sodium channels. According to the I-V curve (current-voltage curve) in Figure panel B, what is the effect of the venom on voltage-gated sodium channels? Current is on the y-axis and voltage is on the x-axis during an action potential. The figure legend denotes the concentration of the venom being applied. A rHNTX-IV (10 μM) rHNTX-IV (100 nM) Control 5 nA 10 ms B -80 -60 V(mv) -40 -20 J -6 I (NA) -8 -10 -12 -Control -- 100 nM — 10 μM 40

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Below is a figure from a 2015 paper that characterizes the effect of venom from the spider Selenocosmia hainana on
voltage-gated sodium channels. According to the I-V curve (current-voltage curve) in Figure panel B, what is the effect of
the venom on voltage-gated sodium channels? Current is on the y-axis and voltage is on the x-axis during an action
potential. The figure legend denotes the concentration of the venom being applied.
A
C
rHNTX-IV (10 μM)
-rHNTX-IV (100 nM)
Control
Control
5 nA
10 ms
r
5 nA
10 ms
rHNTX- IV (10 μM)
B
D
-80
-80
-60
-60
A
-40
-40
V (mv)
-20
V(mv)
-20
be
TOLF
2-6 I (NA)
-8
ON
-12
10
-12
-14
-8
-10
(NA)
Control
100 nM
— 10 μΜ
40
-Control
-- 10 μM
40
Transcribed Image Text:Below is a figure from a 2015 paper that characterizes the effect of venom from the spider Selenocosmia hainana on voltage-gated sodium channels. According to the I-V curve (current-voltage curve) in Figure panel B, what is the effect of the venom on voltage-gated sodium channels? Current is on the y-axis and voltage is on the x-axis during an action potential. The figure legend denotes the concentration of the venom being applied. A C rHNTX-IV (10 μM) -rHNTX-IV (100 nM) Control Control 5 nA 10 ms r 5 nA 10 ms rHNTX- IV (10 μM) B D -80 -80 -60 -60 A -40 -40 V (mv) -20 V(mv) -20 be TOLF 2-6 I (NA) -8 ON -12 10 -12 -14 -8 -10 (NA) Control 100 nM — 10 μΜ 40 -Control -- 10 μM 40
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