Based on studies, synaptotagmin is a crucial protein anchored to the vesicle and it is activated by binding to a) A RIM-BP protein anchore b) phosphorylation c) A SNAP-25 complex d) five Ca2+ via its C2A and C2B domains

What is the natural function ofPTEN?

Q18

39)Start and stop signal sequences on a newly translated protein A) Tell the ribosomes when to move to the nucleus B) Help position it within the ER membrane correctly C) Indicate where glycosylation should occur D) Are important for protein modifications in the smooth ER E) Are added in the golgi apparatus

In both Prokaryotes and Eukaryotes, which of the following structures can cross cell membranes using the same protein channels as water? A) mRNA, B) triglycerides, C) large, non-polar molecules, D) DNA, E) gases (CO2 and O2) and small ions.

The new E484K mutation in SARS-CoV Spike produces a) a change from a hydrophillic to a hydrophopic patch on the surface of Spike B. a change from hydrophobic to a hydrophilic patch in the buried interior of Spike c) a change in charge on the surface of Spike d) a change in charge in the buried interior of Spike

In the motor protein diagram shown below, the part that binds to the cargo is labeled....... and the part that binds to the cytoskeleton is labeled......

4. i)List two reasons why membrane fusion is energy demanding. ii) List the three SNARE proteins which catalyze fusion of vesicle with target membranes and specify their localizations. iii) Briefly describe the structures of SNARE proteins and SNARE complex. iv) What does botulism neurotoxins do to SNARE proteins? How do these toxins lead to muscle paralysis? 5. How does the structure of the potassium channel promote specific binding of potassium?

How do the Arp2/3 complex and NPFs nucleate the assembly of actin filaments?

1- Vesicular transport occurs through budding of clathrin-coated vesicles from eucaryotic plasma membrane through various types of proteins including adaptins, clathrin, and dynamin-GTP which are added to the membrane preparation. What would happenes if these are mutated or omitted (A) adaptins? (B) clathrin? (C) dynamin? (D) What would you observe if the plasma membrane were from bacteria? coated vesicle clathrin coat UNCOATING VESICLE FORMATION adaptin cargo receptor -adaptin naked transport vesicle dynamin CYTOSOL EXTRACELLULAR SPACE cargo molecules