(b) ☐ The exergonic reactions catalyzed byisocitrate dehydrogenase (ICDH) and α-ketoglutarate dehydroge-nase (aKGDH) are regu-lated by metabolites, in addition to the reactioncatalyzed by citrate synthase. The diagram to theright illustrates the activity of ICDH (A,▲) andaKGDH (O,●) in the presence of 1.5 mM ADP(O,A) or 1.5 mM ATP (●,▲). In muscle tissuecontraction of sarcomeres initiated by a nerve im-pulse results first in the release of Ca 2+ from thesarcoplasmic reticulum. As indicated by the chang-es in velocity of the two enzymes, what are the fluxchanges of the TCA cycle in muscle tissue uponrelease of Ca2+ under the influence of ADP viz. ATPand under the influence of NAD+ viz. NADH on cit-rate synthase?10075Stimulation of activity(% of maximum)ŏ251.-8-7-6log {[Ca2+] (M)}

Isocitrate Dehydrogenase (ICDH): Function: ICDH plays a crucial role in the TCA cycle by catalyzing…

Answered: (b) ☐ The exergonic reactions catalyzed…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter25: Nitrogen Acquisition And Amino Acid Metabolism

Section: Chapter Questions

Problem 12P

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