b) Determine which ionization state corresponds to aspartic acid (shown below) atpH 1, 7, and 10 by selecting the most suitable answer from the statements i-iv. ThepK of the amine, carboxylic acid, and side chain of aspartic acid are 9.6, 1.88 and 3.65,respectively.ОНÓHÑH2i) the amine is charged; the carboxylic acids are neutral.ii) the amine and carboxylic acids are all charged.iii) the amine is neutral, and the carboxylic acids are charged.iv) the amine and the carboxylic acids are all neutral.pHStatement (i, ii, iii, or iv)1710%3D

Due to the presence of ionizable groups, the amino acids possess different charges at different pHs.…

Answered: b) Determine which ionization state…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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a) Which pH (1, 7 or 10) would produce the following ionization states for lysine?The pK of the amine, carboxylic acid, and side-chain are 8.95, 2.18 and 10.53, respectively. A В C H2N. H;N. HO "NH3 NH3 NH3
Glutamic acid (1one of the 20 amino acids) has a side- chain carboxyl group (COOH, pKa = 4.3) as shown in Figures 4.7 and 4.8 a. Write the chemical equation for the dissociation of the side chain COOH. Label the weak acid and the conjugate base. b. The Henderson-Hasselbalch Equation (shown below) can be used to determine the ionization status of a weak acid: pH = pKa + log [base] Use the Henderson Hasselbalch equation to determine whether the glutamic acid side chain [acid] • carboxyl group is protonated or deprotonated at physiological pH.
The skeletal structures of the two amino acids, glycine and lysine, are given below along with the values of the relevant acid dissociation constants (pKa). NH,* PK, - 10.79 - HạN*CH2CO,¯ S pK¸=2.35 (CH2)4 - H3N*CHCO,- pK,=9,78 lysine (Lys) glycine (Gly) pK, = 9.18 pK, - 2.16 For an aqueous solution of glycine alone, calculate the value of pH at which the ratio of the concentration of neutral glycine zwitterions to the concentration of protonated cation is 102. On your under each of the following conditions. In the blank, provide the total charge of the dipeptide. (Example: If the charge is two plus write the answer simply as 2, if the charge is negative two write the answer as -2). draw the skeletal structure of the dipeptide, Lys-Gly, when it is solvated in an aque us solution i. pH= 1 ii. pH= 12
Glycine hydrochloride (Cl− H3N+CH2COOH) is a diprotic acid that contains a carboxylic acid group and an ammonium group and is therefore called an amino acid. It is often used in biochemical buffers. Solve, (b) Write the chemical equations describing the dissociation of the first and second protons of Cl−H3N+CH2COOH.
Psilocybin is a natural product of psychotropic "magic" mushrooms and has the Following structure: HO HO O=0 Psilocybin The pK a Of the first phosphate oxygen is 1.3, the pK. Of the second phosphate oxygen is 6.2, And the pKa Of the tertiary amine is 10.4. What is the average charge of psilocybin when Dissolved in your carbonic acid buffer of pH=6?
What is the pH of a glycine solution in which the alpha-carboxyl group is one third dissociated? Given pka1=2.3, pka2=9.6
The free energy of hydrolysis for acetic anhydride is221.8 kJ/ mol. The conversion of ATP to ADP also involvesthe cleavage of an anhydride bond. Its free energy of hydrolysis is 230 kJ/ mol. Explain the difference in these values.
The following amino acid is dissolved in solution at pH 7.4. HC H' + CH CH₂ H/ H+ HC a. Which amino acid is this? (all lower case) N- H CH CH₂ b. What is the pKa of its ionizable side chain? (Use the value from the textbook.) c. What is the ratio of the uncharged to the charged form at pH 7.4? (write answer as number with one decimal place, ex 2.5 or 0.2 or 50.0 with an implicit "to 1")
Given the titration curve of the hypothetical polyprotic acid X at 0.100 M concentration (pKa1=4.0, pKa2=8.0, pKa3=12.0) titrated with 0.600 M NaOH, identify the pH at point C, H, E, and M.
The amino acid arginine ionizes according to the following scheme: NH₂ I C=N I ΝΗ Part A pl = Submit H (CH₂)3 H-N-C-COOH II HH 1 [ΠΙ ΑΣΦ H H Calculate the isoelectric point of arginine. Express your answer using three significant figures. Request Answer pk-2.17 -H* +H* wwwww NH₂ C=N ΝΗ H (CH₂)3 1 ? H H-N-C-COO- | | H H 11 H pk-8.99 -H* +H* NH₂ I C=N I ΝΗ T (CH₂)3 H H H₂N-C-COO- I H pk - 12.5 -H* +H* NH₂ C=N=H NH I (CH₂)3 H₂N-C-COO- I H IV
For an acid HA, the concentrations of HA and A are 0.075 and 0.025, respectively, at pH 6.0. What is the p K a value for HA?
Acetic acid is the principal ingredient in vinegar as shown; that's why it tastes sour. At equilibrium, a solution contains [CH3CO2H] = 0.0787 M and [H3 O+] = [CH3 CO2−] = 0.00118 M. What is the value of Ka for acetic acid?

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