ATP Synthase contains with in it one of the most conserved residues in a protein we know. Asp 61. This is the amino acid that carries the proton. a. Why would this residue be so highly conserved? What would happen if a mutation occurred that would change Asp to Ala? b. At the end of one spin of ATP synthase when the proton is in a position to leave to the intermembrane space the Asp comes into close contact with another very highly conserved residue Arg 210. Explain how this Arg residue could help the proton attached to Asp to leave. Hint think pKa  Answer both parts with good explanation

Human Anatomy & Physiology (11th Edition)
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 ATP Synthase contains with in it one of the most conserved residues in a protein we know. Asp 
61. This is the amino acid that carries the proton. 
a. Why would this residue be so highly conserved? What would happen if a mutation 
occurred that would change Asp to Ala? 
b. At the end of one spin of ATP synthase when the proton is in a position to leave to the 
intermembrane space the Asp comes into close contact with another very highly 
conserved residue Arg 210. Explain how this Arg residue could help the proton attached 
to Asp to leave. Hint think pKa 

Answer both parts with good explanation 

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