Biochemistry
Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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2+
The activity of the Ca 2+ -ATPase is regulated reversibly under
normal conditions to maintain homeostatic concentrations of Ca²-
inside the sarcomere. However, in a rare genetic disorder, irreversible
activation of the Ca 2+ -ATPase can occur. Assuming 37 °C,
pH = 7.4, and the steadystate concentrations for ATP, ADP Pi,
and Ca2+
(out) given in part (a), calculate the minimum [Ca2+] inside
a sarcomere that has irreversibly activated Ca 2+ -ATPase (i.e., the
Ca2+-ATPase activity is always “on”).
Express your answer to two significant figures and include the
appropriate units.
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Transcribed Image Text:2+ The activity of the Ca 2+ -ATPase is regulated reversibly under normal conditions to maintain homeostatic concentrations of Ca²- inside the sarcomere. However, in a rare genetic disorder, irreversible activation of the Ca 2+ -ATPase can occur. Assuming 37 °C, pH = 7.4, and the steadystate concentrations for ATP, ADP Pi, and Ca2+ (out) given in part (a), calculate the minimum [Ca2+] inside a sarcomere that has irreversibly activated Ca 2+ -ATPase (i.e., the Ca2+-ATPase activity is always “on”). Express your answer to two significant figures and include the appropriate units.
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