At what stage of the drug development pathways can molecular conjugation and bioconjugation based drug optimisations take place?

Q: How can we be sure that the insertion of the therapeutic gene does not harm some other necessary…

A: The Food and Drug Administration still has not approved any human gene therapy product. Current gene…

Q: Venurafenib Select one: a. Was developed as a treatment of Gleevec-resistant CML patients b.…

A: Vemurafenib is an inhibitor of B-RAF enzyme and the name is derived from V600E mutated BRAF…

Q: Explain the Retroviral vectors of Gene Therapy ?

A: Retrovirus is used to infect the mammalian cells as they used host cells to multiply. Retrovirus is…

Q: How might genomic information be helpful for the effective use of imatinib mesylate (Gleevec) in…

A: Imatinib mesylate is a drug used for the treatment of myeloid leukemia that is caused due to…

Q: Discuss the possible advantages of quorum sensingproteins as antibiotic targets

A: Quorum sensing enables the bacteria to detect and respond to the cell population density by gene…

Q: What are drug-resistance gene?

A: Antibiotics are agents or medications used to prevent infections caused by microorganisms. It works…

Q: what are the facilated transport system for drug absorption?

A: Facilitated transport is a special kind of passive diffusion of molecules across the plasma membrane…

Q: In addition to the many pharmaceutical products available to treat various diseases, there are also…

A: Natural Remedies or herbal medicines have been used in many countries for many years. Our nature has…

Q: What is the difference between REGULATORY VS SUBSTRATE DEPENDENT PATHWAYs. consider WT, single…

A: There are two types of paths available. Regulatory routes and assembly or metabolic processes have…

Q: How to use gene therapy help in the cure of COVID-19?

A: Gene therapy is a treatment for the disease in which through a gene delivery vehicle the exogenous…

Q: Are drugs that target cell wall synthesis effective for all bacteria?

A: Introduction Drugs are chemical substances that are used to prevent the growth of pathogens.…

Q: What would likely result from a mutation in the lac operon promoter that increases the number of RNA…

A: RNA polymerase is the enzyme that polymerises messenger RNA (mRNA) over the DNA molecule. This…

Q: What mechanism of antibiotic resistance does the NDM gene code for?

A: Antibiotic Resistance is the phenomenon by which any bacteria can survive in the presence of…

Q: Which mutation would lead to no attenuation, but still allow for transcription and translation of…

A: In tryptophan operon there are four sequence sequence 1, 2, 3 and 4.  There are two sequences that…

Q: Describe how you would genetically design a superbug resistant to β-lactams, methicillin,…

A: Superbugs are varieties of bacteria, viruses, parasites, and fungi that can survive most antibiotics…

Q: Explain how different types of reversible inhibitors can be identified.

A: An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

Q: hat is the similarity of experimen vitamin c assay and the clearance of a molecule like glucose by…

A: A vitamin assay is the measurement of the activity or presence of a specific component in a specific…

Q: What are the two type of viral vector involved in gene therapy trials?

A: Viral vectors are the engineered tools which are used by molecular biologists to transfer genetic…

Q: How can disease biomarkers be used in the future more efficiently for clinical purpose to treat…

A: Biomarkers are chemical or molecular alterations that can be measured in biological media such as…

Q: what is Gleevec ? What does it Target in cancer cells ?

A: Gleevec also known as Imatinib is a drug that are useful to treat different types of cancer such as…

Q: explain  Resistance plasmids

A: Plasmid is a genetic structure in a cell that can replicate independently of the chromosomes,…

Q: What is o A vector derived from the tumor-inducing (Ti) plasmid of the bacterium Agrobacterium…

A: In recombinant technology, vectors are the DNA molecules that are used as a vehicle which carry…

Q: '. Propose synthetic pathways for the following nucleotide sugar inter- mediates involved in the…

A: Lipopolysaccharides determines the virulence of Salmonella typhimurium. Diversity of bacterial…

Q: When ligand bin

A: 23) the correct answer is B) Animal cells respond to hormones produced by bacteria.   These hormones…

Q: a с STARR-seq construct ORF hkCP or dCP Enhancer ORF hkCP S2 STARR-seq 1,822 4,134 (32%) 3,586 pA…

A: The sets of genes in our genome can be broadly divided into 2 groups; Housekeeping genes and…

Q: What are the effects of the following conditions on Lac operon of bacteria? Do not forget to mention…

A: Lac Operon helps in the metabolism of lactose in bacteria.

Q: How antiterminator hairpin is formed ?

A: Introduction: An operon is defined as a group of genes that have a common promoter and regulator and…

Q: How do knockout and knock-in animals provide better predictions of how a drug will work in humans?

A: In order to discover a drug and test its efficiency, laboratory tests are conducted in animals such…

Q: What is Stem cell therapy for Covid-19? and What could be its possibilities and challenges?

A: Severe Acute Respiratory Syndrome coronavirus(SARD-CoV)-19 is the virus responsible for novel corona…

Q: Describe the mechanism through which oseltamivir (Tamiflu) inhibits influenza virus reproduction.

A: Oseltamivir (also known as TamifluR) is an antiviral neuraminidase inhibitor used to treat and…

Q: Discuss the advantages and disadvantages of general chemotherapy like Etoposide compared to specific…

A: Chemotherapy is a treatment that involves a combination of drugs used to treat cancer in which…

Q: How does bisulfite treatment coupled with PCR enable the identification of DNA methylation? And, How…

A: DNA methylation is an essential epigenetic process that plays a key role in various biological…

Q: Explain how COVID-19 can be detect using molecular based

A: Given: Need to find how the COVID-19- can be detected using molecular based technology. Coronavirus…

Q: Which of the candidate genes would be good targets to develop potential therapeutics using SİRNA…

A: According to the question, we have to mention which of the candidate genes would be good targets to…

Q: How to test in vitro metabolic stability of new drug molecules?

A: Introduction:- Metabolic stability is defined as the interaction of chemical compounds in…

Q: What are the implications of resistance gene transfer for the future practice of medicine?

A: Bacteria multiply quickly and have a variety of methods for exchanging DNA. This is how they are…

Q: Describe the generation of multiple-drug-resistantplasmids

A: Drug inactivation or modification is one mechanism of drug resistance. Changes to the target site.…

Clinical Pharmacology

Pharmacology is a discipline of medicine that studies how medications interact with the systems and processes of living organisms, focusing on drug action mechanisms as well as therapeutic and other purposes.