Are redundant genes revealed by loss-of-function or gain-of-function alleles and why is that the case?

Q: Which allele directs the production of higher levels of functional Rugose protein?

A: The rugose gene plays a crucial role in the formation of the correct retinal pattern in the eye. It…

Q: How we can know the rare inherited genetic disorders by the incidence ? Explain

A: Inheritance is the process of transmitting the traits from parent to offspring. Traits of an…

Q: Is Miller Fisher syndrome hereditary?

A: Miller Fischer syndrome is a rare acquired nerve disorder that is characterized by abnormal muscle…

Q: What is Down syndrome ? When does Down syndrome occur ?

A: Human genetic disorders are caused due to the absence or excess or abnormal arrangement of one or…

Q: the possible alleles for bald spot, no bald spot are QQ, Qq.    what type of inheritance pattern…

A: Introduction :- Alleles are the alternative forms of a gene . Allele shows different Types of…

Q: What is the difference in the studied skin color gene between dark skinned and light skinned people?

A: Human skin color can range from the darkest brown to the lightest hues. Differences in skin color…

Q: Which are the two kinds of biological abnormalities that could conceivably be inherited ?

A: Biological abnormalities refer to any condition of the body that alters from the normal parameter;…

Q: what is dosage compensation.?

A: Sex of an organism in various species depends on the type and number of sex chromosomes. In species…

Q: What are Possible Dominance Relations in case of hypermorphic mutations?

A: A hypermorphic mutation induces an change in the activity of the regular gene[1]. Hypermorphic…

Q: What are three common inheritance patterns for human monogenic diseases?

A: According to the question, we have to provide the name of three common inheritance patterns for…

Q: Define ‘gene’. What is an allele and loss-of-function alleles? What do these alleles tell us about…

A: "a DNA phase that contributes to the phenotype/characteristic of an organism."

Q: Why does a loss or an excess in genetic material lead to the expression of an abnormal phenotype?

A: Mutations are changes in the DNA sequence. Mutations can occur as a result of errors in DNA copying…

Q: What is the difference between broad-sense heritability and narrow-sense heritability? Why is…

A: Heritability is defined as the amount of phenotype variance within a population due to the genetic…

Q: What are the possible genotypes of the PTC locus?

A: * genotype means collection of genes that  refers to two alleles of a particular gene and genotype…

Q: Which are the components of phenotypic variance?

A: Phenotypic variance is defined as the change in the gene expression in response to the environmental…

Q: Why Recessive CF disease alleles either produce no CFTR or produce nonfunctional or less functional…

A: Cystic fibrosis (CF) is a classical example of recessive disease. It is a disease that is inherited.

Q: Why do most cases of Down syndrome originate from the mother? And how is this linked to maternal age…

A: Down syndrome also called "trisomy 21" is a condition in which a child is born having an additional…

Q: Explain why most loss-of-function alleles are recessive to wild-type, but some are incompletely…

A: An allele determines the hereditary characteristics. Most of the genes have two alleles, namely the…

Q: How many alleles does each of the 3 histocompatibility genes have?

A: Antigens are substances that activate the immune system of the body. Antibodies are antigen-binding…

Q: Why are maternal effect genes so difficult to identify via mutant analysis?

A: Introduction :- In an offspring , the genes are contributed by both of the parents but the mother…

Q: Why the allele for Huntington disease is dominant?

A: Step 1 Huntington disease is an inherited disorder that causes the death of brain cells by the…

Q: Is the sickle cell allele dominant or recessive? Explain. What is sickle cell trait?

A: Sickle cell is a red blood cell trait. The red blood cells become sickle cell in shape.

Q: which mode of inheritance does this trait show (autosomal recessive, autosomal dominant, X-linked…

A: The given image is of a pedigree chart. Squares represent males and circles represent females. Black…

Q: What is the difference between primary Down syndrome and familial Down syndrome? How does each type…

A: Trisomy is the addition of a single chromosome in the whole set of chromosome. Addition of single…

Q: determining coat color is the agouti gene?

A: The coloration, pattern, and length of the cat fur is governed by numerous genes and is determined…

Q: What are Possible Dominance Relations in case of neomorphic mutations?

A: Any permanent change in the DNA’s nucleotide sequence is termed as mutations. Based on their effect…

Q: What are The effects of random events on penetrance and expressivity?

A: Genotype- It is the set of genes that we have inherited from our parents and will pass on these…

Q: What characteristics are exhibited by a Y-linked trait?

A: Genetic material is any material of animal, microbial, or plants, or other origin that carries…

Q: what is the general definition of gene drive and how does it differ from a gene expression pattern…

A: Gene drives can arise through a variety of mechanisms. They have been proposed to provide an…

Q: Over a thousand different alleles at the CFTR locus have been discovered that can cause cystic…

A: Cystic fibrosis (CF) is a genetic illness that makes bodily fluid develop in a patient's lungs.…

Q: What is one-way genetic background can affect phenotypic expression?

A: Phenotypes are the characteristic traits expressed by an individual. Whereas genotype is the genetic…

Q: For two genes that show independent assortment, what is the frequency ofrecombination?

A: Gene is the working part of hereditary material. The study of genes is genetics. Gregor Mendel is…

Q: a. What are the other systems of blood typing? What are the modes of inheritance of these groups?…

A: A blood group is usually controlled by a series of gene, which is comprised of RBCs. 1900 Karl…

Q: b. How is the inheritance pattern of Jervell and Lange-Nielsen syndrome similar to that of familial…

A: Long QT syndrome is a heart condition in which the heart's electrical system is abnormal. The heart…

Q: What is the unusual phenomenon in which the expression of an allele depends on the parent that…

A: A gene is a unit of genetic material and alleles are the alternative form of genes present on the…

Q: The karyotypes shown here depict chromosomal abnormalities. Name the syndromes and if they are male…

A: "Genes" are the fundamental unit of heredity. They store genetic information in the form of DNA,…

Q: What is the Characteristic pedigree for mitochondrial disease?

A: The genes located on the nuclear chromosomes obey the Mendelian law of inheritance. In the human…

Q: Are changes that cause high FST found equally across the genome? What areas of the genome would be…

A: The fixation index is a measure of the population difference due to the genetic structure. It is the…

Q: Due to dosage compensation by X inactivation, females can exhibit a mosaic pattern of sweat glands…

A: X-inactivation refers to the inactivation of one of the X chromosomes that is present in pairs in…

Q: Are all forms of Down syndrome due to non-disjunction?​YES​​​ or NO​?

A: Down syndrome is a genetic disorder caused when abnormal cell division results in an extra full or…

Q: What are allele-specific oligonucleotides,?

A: The blotting technique is the process of transferring the DNA, RNA or proteins present in the…

Q: Pedigrees indicate that color blindness and which two forms of hemophilia are X-linked traits?

A: Introduction  Pedigree Analysis: this is the new approach to study the inheritance pattern in the…

Mitochondrial Mutations

A mitochondrion is a cellular organelle that serves as the site for cellular respiration and energy production (ATP or Adenosine Triphosphate). It is a double-membrane-bound organelle and is only present in eukaryotic cells.