Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Antigen-presenting cells make contact with T-cells via cellular junctions. Which of the following is likely to mediate this junction if liquid can pass between the cells in the extra-cellular matrix but can not pass from cell to cell?
a. Cadherin
b. Connexin
c. COPII
d. Claudin
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- Which of the following statements are true for antigen presentation. a. Antigen presentation means that other cells attach the pathogen first and present it to T cells. b. Antigen-presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor to B cells c. Antigen presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor on their surface. d. Antigen-presenting cells are phagocytic cells e. Antigen presentation is required for T cell activation f. Cytokines released by macrophages are required for T cell activation g. T cell receptors recognize the MHC receptors in complex with antigen fragments displayed by antigen-presenting cells. h. Phagocytic cells are involved in innate immunity. Therefore they have no role in T-cell activationarrow_forwardExplain why each choice (a-d) is correct or incorrect. Allergens differ from antigens because a. Allergens produce an abnormally large immune response to what is an otherwise harmless particle. b. Allergens do not involve the leucocytes, they simple stimulate the inflammatory response. c. Allergens are only active seasonally and are generally harmless to the body. d. Allergens are primarily plant derived while antigens are bacterial or viral in nature.arrow_forwardWhich of the following cell types is unable to interact with naive T cells and induce their activation? (Select all that apply.) a. B cells b. macrophages resident in infected tissues c. macrophages resident in secondary lymphoid tissue d. interdigitating reticular cells e. immature dendritic cells.arrow_forward
- Each of the following statements is false. Please correct. a. Mature T cells are found only in the lymph nodes and spleen b. The pluripotent stem cell is one of the most abundant cell types in the bone marrow c. There are no stem cells in blood d. Activation of macrophages increases their expression of MHC class I molecules, allowing them to present antigen to CD4+ TH cells more effectively e. B cells develop in the thymus f. Lymphoid follicles are present only in the spleen and lymph nodes g. The FRC guides B cells to follicles h. Infection has no influence on the rate of hematopoiesis i. Follicular dendritic cells can process and present antigen to T lymphocytes j. Dendritic cells arise only from the myeloid lineage k. All lymphoid cells have antigen-specific receptors on their membrane l. All vertebrates generate B lymphocytes in bone marrow m. Only mammals have a thymus n. Jawless vertebrates do not have lymphocytesarrow_forwardGive ONE example of how a defect in a T Reg cell could lead to an immunological disorder or disease.arrow_forwardExplain why each choice (a-d) is correct or incorrect. In order for an antigen to activate or sensitize a T helper cell, the antigen must be a. coated with antibodies b. displayed on the surface of an APC along with MHC antigens c. displayed on the surface of another T cell with IgD antibodies d. partly digested by a natural killer cellarrow_forward
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