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Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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
Transcribed Image Text:Acetylation is a post-translational modification that is used in the regulation of
enzymes. An acetyl group is usually added to a lysine side chain in an enzyme
(see the picture).
Choose the best explanation for how this process affects the enzyme.
WHN.
NH₂
Om
1
متر
wHN.
NH
A) The acetyl group changes the charge on the
side chain from a positive charge to neutral.
This causes a change in conformation which
affects the activity of the enzyme.
B) The acetyl group changes the charge on the
side chain from neutral to a positive charge.
This causes a change in conformation which
affects the activity of the enzyme.
C) The acetyl group is a cofactor that binds
tightly to the enzyme through intermolecular
forces. This cofactor activates the enzyme.
D) The acetyl group binds two side chains
together closing the active site which affects the
activity of the enzyme.
Expert Solution
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