A variant of hemoglobin (Boston variant; mutation His E7(58)α → Tyr) promotes methemoglobin formation involving the α (alpha) subunits. What is the maximum value of the Hill constant (n) that you could measure for the Boston variant of hemoglobin?   log (YO2 / 1 - YO2 ) = log pO2 - logP50 Please break down each step of the Hill equation and explain why the result for n is valid from a logical standpoint.

Q: Explain the molecular basis behind the reported observation in the parameter measured below:

A: Obesity results from high calorie intake than calorie burned by daily activities or exercise. A…

Q: Two co-op students at your start-up company have been asked to evaluate the rate of reaction…

A: An enzyme is a cellular catalyst that speeds up chemical reactions. Proteins that bind to…

Q: Human serum transferrin is an iron transport protein. With the use of appropriate diagrams, describe…

A: Transferrin protein is a protein complex, which is known to transfer iron molecules to the cell.

Q: Molecular diameters of proteins IgG and TNFα are 11.2 nm and 4.4 nm, respectively. The  diffusion…

A: Stokes-Einstein equation is the relationship between radius and diffusion coefficient of a substance…

Q: From the figure of O2 binding to myoglobin and hemoglobin (ignore the line marked as T) as described…

A: The body receives nutrition, oxygen, and waste removal from the blood, which is a fluid that…

Q: The gamma and beta subunits that make up fetal and adult hemoglobin, respectively, differ in a…

A: BPG is 2,3-bisphosphoglycerate, which produced in the respiring tissue as a byproduct of glucose…

Q: Using the graph data I estimated Slope = 2.8, about the same as the steeper part of the maternal…

A: Hemoglobin (Hb) is composed of 4 polypeptide chains. Adult Hb has 2 alpha chains and 2 beta chains…

Q: A different Fab fragment binds to lysozyme with a dissociation constant of Kd=10-6 M. A 1 nM (10-9…

A: Consider the following reaction: where P is the protein, L is the ligand and k1 and k2 are rate…

Q: Normal Hgb is referred to as HbA and contains 4 subunits, 2 α-globin chains and 2 β-globin chains,…

A: The protein structure has different levels:- Primary structure: refers to the normal amino acid…

Q: under the same conditions. Fetal erythrocytes contain a structural variant of hemoglobin, HbF,…

A: Hemoglobin is a protein present in the blood. it is the most important iron containing protein which…

Q: One of the treatments for sickle cell anemia is hydroxyurea, which is known to induce the expression…

A: The most important mutation is the third one where serine replaces histidine. Whereas histidine is…

Q: Give the general Adiar equation for the binding of a ligand to a dimeric protein. Explain further…

A: Cooperativity- It is a character of some multi-subunit enzymes, where different subunits has…

Q: Hb Great Lakes 0.8 1. ;) The diagram on the right compares the O2 binding prop- erties or normal…

A: Hill plot for O2 binding to hemoglobin (Hb) has log(pO2) as X-axis and  as Y-axis. We are given…

Q: Imagine there is a beaker with a solution containing 1,000 hemoglobin homotetramers and 1,000…

A: Hemoglobin is a protein found in the red blood cells that are involved in the transport of carbon…

Q: Crystal structures exist for three neurokinin-1 (NK1) ligand complexes with the following pdb codes…

A: NK1 is a type of mammalian tachykinin receptors. These are G-protein coupled receptors which are…

Q: Calculate the fractional saturation for emperor penguin myoglobin, which has a p50 value of 2.5…

A: Fractional saturation of myoglobin refers to proportion of mygloglobin that is bound to oxygen. p50-…

Q: Sickle cell anemia is associated with which of the following:   Question 27 options:   Sticky…

A: Sickle cell anemia : It is caused by the single acidic amino acid substitution, Glu 6th position to…

Q: One can identify phenylketonurics and PKU carriers (heterozygotes) by means of a phenylalanine…

A: The graph that shows different patients at different conditions between relative serum…

Q: The distal Histidine (His 64) in myoglobin is subjected to three different mutations, this is one of…

A: Both hemoglobin and myoglobin are oxygen binding proteins which are found in the red blood cells…

Q: Bovine ribonuclease folds with ΔH° = -280 kJ mol-1 and ΔS° = -0.79 kJ mol-1 K -1. Assume ΔH° and ΔS°…

A: The basis for predicting spontaneity of a reaction is based on (ΔG), the change in G, at constant T…

Q: The following data describe binding of ligand A to a protein, using both Scatchard plots and Hills…

A: Scatchard plots is used to determine the affinity of the receptor or any protein for its ligand and…

Q: Certain individuals with mild forms ofβ-thalassemia produce, in addition to normal adulthemoglobin…

A: Haemoglobin lepore is defined as a small group consisting of structurally abnormal haemoglobins…

Q: whereas protein B does not absorb at 340 nm. What absorbance will be observed when light at 340 nm…

A: Given, ε (extinction coefficient) = 6440 M-1 cm-1 l (path length) = 5 mm = 0.5 cm c (concentration)…

Q: The specific activity of a pure preparation of pyruvate kinase (PK) assayed in the direction of…

A: Pyruvate kinase (PK): The role of pyruvate kinase is to catalyze the final phase of glycolysis,…

Q: SARS-CoV-2 Spike protein variant Wuhan Alpha Beta Delta Omicron KD, nM 60 9.6 2.4 1.2 2.4 Using the…

A: Consider a protein 'P' that can bind with 5 different ligands; L1, L2, L3 , L4 and L5.The…

Q: Substrate A has a Km of 45uM and a kcat of 100/s with trypsin and a Km of 540mM and a kcat of 2/s…

A: Enzymes are the proteinous structure that helps in increasing the rate of metabolism. The function…

Q: Dr Merrick is so excited to know the affinity constant Kd values for O2 binding to mammoth OBP and…

A: ANSWER;- It is given that the ka values of OBP and elephants Hb are the same at pH=7. Kd is the…

Q: Describe the concept of isoelectric point and calculate the PI for isoleucine?

A: Isoelectric point is the pH value at which the charge on an amino acid is zero.

Q: Using the information given, determine the Kd for the binding of HABA to BSA. B= y-intercept (E…

A: Y=mx+b is the equation of a line that is not passing through the origin. In this equation, m is the…

Q: Based on the following data, is the p50 higher or lower than normal in (a) hemoglobin Yakima and (b)…

A: P50 is defined as the oxygen tension at which haemoglobin is 50%saturated with oxygen .When…

Q: Oxygen affinity of fetal blood is higher than that of maternal blood and may help to provide the…

A: Answer: Triangle is the correct option.

Q: What is the dominant biochemical activity or molecular interaction that Sickle Cell Anemia…

A: Hemoglobin is an oligomeric conjugated protein with four peptide chains joined by a…

Q: 54.  2,3-Bisphosphoglycerate: (MARK ALL THAT APPLY) Group of answer choices is absorbed from food…

A: Oxygen transport occurs with the help of hemoglobin. Hemoglobin is a type of conjugated protein.…

Q: A) 43 14 When Friend erythroleukemic cells are incubated with sodium butyrate, they differentiate…

A: Introduction :  Histones are highly alkaline proteins. They are found in the nucleus of the…

Q: Given a tripeptide Cys-His-Lys, Cys: Pk1 = 1.5; Pk2 = 10.8; PkR = 8.5 His: Pk1 = 1.6; Pk2 = 9.0; PkR…

A: Hi. Thank you for the question, As per the honor code, we are allowed to answer three sub-parts at a…

Q: How does the difference between the-chain and the -chain of hemoglobin explain the differences…

A: Hemoglobin is an oligomeric, allosteric, conjugated protein with four polypeptide chains joined by…

Q: r^2=6Dt , where D is the diffusion coefficient of thediffusing object  and t is the  time that the…

A: The objective of the question is to find out the time it takes for a protein to diffuse across a…

Q: If instead of using 3.5 µM myoglobin (receptor) you used half of this (that is, 1.75 µM myoglobin),…

A: Myoglobin is a protein located primarily in striated muscles of the vertebrates. MB is the gene…

Q: You are studying how your Lys-Val-Thr tripep de interacts with another pep de, which places an Asp…

A: Eventhough all ionizable groups have their characteristic pKa value, the pKa value of an ionizable…

Q: A one-to-one protein (P)-ligand (L) complexation (P + L PL) has a equilibrium constant (Kd) value…

A: ∆Cp is the heat capacity at constant pressure. ∆S is change in entropy, degree of randomness. At…

Q: Fetal hemoglobin binds to BPG to a lesser extent than does HbA because His 143 in the BPG binding…

A: RBCs contain hemoglobin, the protein that transports oxygen from the lungs to our organs. The adult…

Q: What is the role of 2, 3-Bisphosphoglycerate (2,3-BPG) in the function of haemoglobin as an oxygen…

A: 2, 3-Bisphosphoglycerate (2,3-BPG) is most abundant organic phosphate in the red blood cell. Molar…

Q: Could you please help answer this question?

A: When hemoglobin is 50% saturated with oxygen, then the oxygen tension developed is called as the P50…