A useful technique for studying microtubule motors is to attach them by their tails to a glass coverslip (which can be accomplished quite easily because the tails stick avidly to a clean glass surface) and then allow them to settle. The microtubules may then be viewed in a light microscope as they are propelled over the surface of the coverslip by the heads of the motor proteins. Because the motor proteins attach at random orientations to the coverslip, however, how can they generate coordinated movement of individual microtubules rather than engaging in a tug-of-war? In which direction will microtubules crawl on a ‘bed’ of kinesin molecules (i.e., will they move plus-end first, or minus-end first)?
A useful technique for studying microtubule motors is to attach them by their tails to a glass coverslip (which can be accomplished quite easily because the tails stick avidly to a clean glass surface) and then allow them to settle. The microtubules may then be viewed in a light microscope as they are propelled over the surface of the coverslip by the heads of the motor proteins. Because the motor proteins attach at random orientations to the coverslip, however, how can they generate coordinated movement of individual microtubules rather than engaging in a tug-of-war? In which direction will microtubules crawl on a ‘bed’ of kinesin molecules (i.e., will they move plus-end first, or minus-end first)?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A useful technique for studying microtubule motors is to attach them by their tails to a glass coverslip (which can be accomplished quite easily because the tails stick avidly to a clean glass surface) and then allow them to settle. The microtubules may then be viewed in a light microscope as they are propelled over the surface of the coverslip by the heads of the motor proteins. Because the motor proteins attach at random orientations to the coverslip, however, how can they generate coordinated movement of individual microtubules rather than engaging in a tug-of-war? In which direction will microtubules crawl on a ‘bed’ of kinesin molecules (i.e., will they move plus-end first, or minus-end first)?
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