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- C. What types of inhibitors of this enzyme is shown below? [1]. D. What effect (increase, decrease, stay the same) does the inhibitor have on Vmax? E. What effect (increase, decrease, stay the same) does the inhibitor have on Km?Visit this site (http://openstaxcollege.org/l/normallevels) for a list of normal levels established for many of the substances found in a sample of blood. Serum, one of the specimen types included, refers to a sample of plasma after clotting factors have been removed. What types of measurements are given for levels of glucose in the blood?op of Form Normal Levels of Substances in the Arterial Blood: pH 7.40 + 0.05 pCO2 (partial pressure of carbon dioxide) 40 mm Hg pO2 (partial pressure of oxygen) 90 - 100 mm Hg Hemoglobin - O2 saturation 94 - 100 % [HCO3-] 24 meq / liter Vignette #1: A 21-year-old noncompliant female with a history of type I (insulin-dependent) diabetes mellitus was found in a coma. Her blood glucose was high, as well as her urine glucose, urine ketones, and serum ketones. Her serum bicarbonate was < 12 mEq/L. Her respiration was exaggerated, and her breath had an acetone odor. Her blood pressure was 90/60 and his pulse weak and rapid (120). 1. Define noncompliant. 2. Is this person experiencing ketoacidosis or insulin shock? Explain your answer. 3. Why is the serum bicarbonate low? 4. What is the acid-base status of this individual? 5. What are the causes of the dyspnea, hypotension, and tachycardia? 6. What type of treatment does this person need?…
- II Based on the image below, select the correct statement. Complex I Matrix arm NADH Fe-S FMN A 2e™ N-2 2e 2H+ NAD+ + H+ 4H+ QH₂ Intermembrane space (P side) Matrix (N side) Membrane arm https://canvas.uts.edu.au/assessment questions/356985/files/1562692/download? verifier=ePzpZHZuoVcemUMJXLgKrxl Rux2WcX3LR40FKWGq O Ubiquinone (Q) is oxidised to form Ubiquinol (QH2) O Ubiquinone (Q) is reduced to form Ubiquinol (QH2) O Electrons are transferred from FMN to NADH O Electrons are transfered from FMN to NAD+ O Electrons are transferred from Ubiquinone (Q) to Ubiquinol (QH2)For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be used to make this drug more bioavailable after oral administration? This under Bipharmaceurics and Pharmacokinetics subjectWhat is the relationship of glucose urine and glucose carrier protein. Pls explain in the context of diabetic patient.
- enumerate important PK concepts that are of clinical values. Fill out the table below. PHARMACOKINETIC PROCESSES PK concepts Clinical relevance or rationale ABSORPTION DISTRIBUTION METABOLISM EXCRETION What is your idea of (one sentence only): 1. partial agonist/agonism? and; 2. inverse agonist?Discuss how cholesterol is transported between tissues in plasma lipoproteins.Plata concentation AY-- A new drug was administered intravenously, and its plasma levels were measured for several hours. A graph was prepared as shown above, with the plasma levels plotted on a logarithmic ordinate and time on a linear abscissa. It was concluded that the drug has first-order kinetics. From this graph, what is the best estimate of the half-life? Lütfen birini seçin: a. 3 h b. 0,5 h c. 7 h d. 4 h . 1 h
- Explain why reduction in ghrelin secretion in bariatric surgery would be beneficial on glucose homeostasis?Discuss the pathology of a condition in which glucose regulation (in the blood and/or urine) presents problems for patients. What causes this condition? How is glucose monitoring accomplished, and how is it indicative of the patient's level of proper biological function? Explain on a cellular level how this glucose imbalance arises. Also, explain the science behind the monitoring technique. Most importantly, what measures can be taken by patients to correct for this glucose imbalance in the long term? Why do these measures work?Matching :1. MDR protein Part of NAD molecule ______ 2. SGLT Part of FAD molecule _____ 3. Grb-2 Raises intestinal pH _______ 4. Cholecystokinin Oxidizes C-C bonds ___________ 5. Chylomicron Has higher phosphoryl transfer potential than ATP __ 6. Secretin An ABC transporter ______ 7. Niacin Sodium-glucose symporter ______ 8. Flavin Lipoprotein complex ______ 9. FAD Found in EGF pathway _____ Phosphoenolpyruvate Signals release of digestive enzymes