A solution of the enzyme glycogen synthase incubated at 45°C lost 70% of its activity in 3 minutes but when incubated at 45°C in the presence of a very large concentration of its substrate UDP- Glucose, it lost only 3% of its activity in the same amount of time, Why? CH OH CH, OH CH,OH CH,OH HO HO, HO UDP O-0 OH OH NH 5,5,5 CH, OH CHOH CH,OH он он Он он HO UDP-glucose binding makes it easier for the enzyme to unfold. The enzyme likely had phosphate groups added through covalent modification. Interactions with the bound UDP-glucose stabilize the tertiary structure of glycogen synthase. The UDP-Glucose is a positive effector which increases the enzyme activity.

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A solution of the enzyme glycogen synthase incubated at 45°C lost 70% of its activity in 3 minutes
„but when incubated at 45°C in the presence of a very large concentration of its substrate UDP-
Glucose, it lost only 3% of its activity in the same amount of time, Why?
Clu
CH,OH
CH, OH
HO,
он
CH;OH
CH2OH
но
HO
он
HO
UDP
O-P-0
OH
OH
NH
o--o
CH, OH
CH2OH
CH,OH
OH OH
HO
UDP-glucose binding makes it easier for the enzyme to unfold.
The enzyme likely had phosphate groups added through covalent modification.
O Interactions with the bound UDP-glucose stabilize the tertiary structure of glycogen synthase.
The UDP-Glucose is a positíve effector which increases the enzyme activity.
Transcribed Image Text:A solution of the enzyme glycogen synthase incubated at 45°C lost 70% of its activity in 3 minutes „but when incubated at 45°C in the presence of a very large concentration of its substrate UDP- Glucose, it lost only 3% of its activity in the same amount of time, Why? Clu CH,OH CH, OH HO, он CH;OH CH2OH но HO он HO UDP O-P-0 OH OH NH o--o CH, OH CH2OH CH,OH OH OH HO UDP-glucose binding makes it easier for the enzyme to unfold. The enzyme likely had phosphate groups added through covalent modification. O Interactions with the bound UDP-glucose stabilize the tertiary structure of glycogen synthase. The UDP-Glucose is a positíve effector which increases the enzyme activity.
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