A solution of the enzyme glycogen synthase incubated at 45°C lost 70% of its activity in 3 minutes but when incubated at 45°C in the presence of a very large concentration of its substrate UDP- Glucose, it lost only 3% of its activity in the same amount of time, Why? CH OH CH, OH CH,OH CH,OH HO HO, HO UDP O-0 OH OH NH 5,5,5 CH, OH CHOH CH,OH он он Он он HO UDP-glucose binding makes it easier for the enzyme to unfold. The enzyme likely had phosphate groups added through covalent modification. Interactions with the bound UDP-glucose stabilize the tertiary structure of glycogen synthase. The UDP-Glucose is a positive effector which increases the enzyme activity.
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
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