A mutation in p21 that destroys its binding site will

76) Nuclear localization signal can be a. Simple sequence in which we have a stretch of acidic amino acid next to each of b. bipartite nuclear localization signal in which we have a stretch of acidic amino are separated by neutral amino acids. c. Simple sequence in which we have a stretch of basic amino acid next to each of d. bipartite nuclear localization signal in which we have a stretch of acidic amino acids then basic amino acids.

If there is a mutation in importin that prevents it from interacting with the NLS of cargo proteins, what affect, if any, would this have on the UPR (unfolded protein response). A. Ran-GEF would bind to the importin promoting cargo entry into the nucleus and transcription of UPR response genes. B. Gene regulatory protein would not be imported into the nucleus thus preventing transcription of UPR response genes C. MRNA would not be imported into the nucleus thus preventing transcription of UPR response genes D. Ran-GTP would not be imported to the nucleus thus preventing transcription of UPR response genes E. No effect, these are completely unrelated processes.

Which of the following types of mutations would be advantageous to a cancer cell (select all that apply)?   A. An inactivating mutation in a tumor suppressor gene   B. Methylation of the promoter of a tumor suppressor gene   C. An inactivating mutation in an oncogene   D. Mutation that inactivated DNA repair gene   E. An inactivating mutation in an oncogene

Which of the following are characteristics of aging cells (select all that apply)? A. Chronic inflammation results in premature shortening of telomeres B. Lengthening of telomeric DNA sequence C. Accumulation of telomere-dysfunction–induced foci (TIFs) D. Older cells produce more telomerase E. Increased erosion of telomeres

Regulation of cellular activities can be modulated by both transcription factors and proteasomes. Select one: a. False b. True

What is the difference between a proto-oncogene and an oncogene?   a. oncogenes cause benign tumors (polyps), proto-oncogenes cause malignant tumors   b. oncogenes transform cells to hyperproliferation, proto-oncogenes have a normal cellular role   c. oncogenes have undergone post-translational modification, proto-oncogenes have not   d. oncogenes have undergone intron splicing,  proto-oncogenes have not

From the list of answers (A-D) below, select the correct anwer(s). There may be more than one answer. B. During the process of cell division all epigenetic changes are lost. A. Epigenetic changes survive cell division. C. Epigenetic changes have NO role in cell differentiation. D. Each of the 200 types have the same genome, but distinct epigenome, which is important for the process of cell differentiation.

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