A condition known as icthyosis hystrix gravior appeared in a boy in the early eighteenth century. His skin became very thick and formed loose spines that were sloughed off at intervals. When he grew up, this “porcupine man” married and had six sons, all of whom had this condition, and several daughters, all of whom were normal. For four generations, this condition was passed from father to son. From this evidence, what can you postulate about the location of the gene?

In recent years, the country of Zambia in Africa has had increasing cases of malaria. If 8 % of the population is born with a severe form of sickle-cell anemia (ss), what percentage of the population will be more resistant to malaria because they are heterozygous (Ss) for the sickle-cell gene, under the Hardy-Weinberg assumption?

The pedigree pictured is of an extended family where a large percentage of family members develop colon cancer at an early age. In this family, individuals either get colon cancer before the age of 16, or they don’t get it at all. a) Based on the information you have been given, what evidence, if any, suggests an inherited contribution to the development of this disease? b) You take a medical history of all 33 people in the pedigree and discover that a large percentage drink a special coffee on a daily basis, while others do not. The individuals who do not drink coffee are I-1, II-2, II-4, II-9, III-7, III-13, IV-1, and IV-3.  Could drinking this special coffee play a role in colon cancer? Explain.

One of the first drugs used for targeted cancer therapy is tamoxifen, used to treat estrogen-receptor breast cancer. What general conclusions can you draw about the targeted drug therapy and genotype?

Question 15: Consider the consequence if one of the mutations you tested for complementation was a dominant mutation. You should see that complementation tests could not be used to provide information about dominant mutations. a) If a mutation were dominant how would your interpretation of the phenotype of the diploid be altered? No change would occur v b) How would you test whether any of these trp mutations were dominant? There is no way to test fc V

Explain this to me…..

No need to explain 1.) The phenomenon in which gene present on the same chromosome remain together as gametes are produced is knows as A.) non-disjunction B.) cross-over C.) synapsis D.) linkage 2.) Queen Victoria was a carrier of hemophilia, but there is no record of the disease in any of her ancestors. It is reasonable to suggest that she became a carrier of hemophilia as a result of A.) recombination B.) a mutation C.) inbreeding D.) crossing over 3.) How many primary spermatocytes and primary Oo Yates are required to produced 100 sperm and 100 eggs? A.) 25 primary spermatocytes and 25 primary oocytes B.) 100 primary spermatocytes and 100 primary oocytes C.) 25 primary spermatocytes and 100 primary oocytes D.) 100 primary spermatocytes and 25 primary oocytes

How can the retinoblastoma trait be inherited in a dominant fashion if the deletion of the RB gene is recessive to the wild-type RB+ allele?

Assume that the diploid number of a certain species is four chromosomes, two large and two small (2n=4). a)  Of the following figures, which represents a 3n (triploid) cell in mitotic metaphase? b)  For each of the wrong answers from part (a) above, explain briefly why it cannot represent a triploid cell in mitotic metaphase.