A commercial research organization is planning to develop a sensor to detect methyl parathion that may be injected into a water supply by terrorists. The LD50 for methyl parathion is reported to be as low as 6 mg ・ kg−1 for rats. They are assuming a safety factor of 1 × 105 and a volume of liquid ingested equal to a cup of coffee (about 250 mL) in the design of the instrument. What concentration (in mg ・ L−1) must their instrument be able to detect? Using Equation 6–10, the concentration you have calculated, the ingestion rate of 250 mL, an exposure frequency of one day, and exposure duration of one day, an adult malebody weight, and an averaging time of 1 day, estimate the hazard index. The RfD for methyl parathion is 2.5 × 10−4 mg ・ kg−1 ・ d−1 .
A commercial research organization is planning to develop a sensor to detect methyl parathion that may be injected into a water supply by terrorists. The LD50 for methyl parathion is reported to be as low as 6 mg ・ kg−1 for rats. They are assuming a safety factor of 1 × 105 and a volume of liquid ingested equal to a cup of coffee (about 250 mL) in the design of the instrument. What concentration (in mg ・ L−1) must their instrument be able to detect? Using Equation 6–10, the concentration you have calculated, the ingestion rate of 250 mL, an exposure frequency of one day, and exposure duration of one day, an adult malebody weight, and an averaging time of 1 day, estimate the hazard index. The RfD for methyl parathion is 2.5 × 10−4 mg ・ kg−1 ・ d−1 .
Chemistry: Principles and Practice
3rd Edition
ISBN:9780534420123
Author:Daniel L. Reger, Scott R. Goode, David W. Ball, Edward Mercer
Publisher:Daniel L. Reger, Scott R. Goode, David W. Ball, Edward Mercer
Chapter12: Solutions
Section: Chapter Questions
Problem 12.107QE
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A commercial research organization is planning to develop a sensor to detect methyl parathion that may be injected into a water supply by terrorists. The LD50 for methyl parathion is reported to be as low as 6 mg ・ kg−1 for rats. They are assuming a safety factor of 1 × 105 and a volume of liquid ingested equal to a cup of coffee (about 250 mL) in the design of the instrument. What concentration (in mg ・ L−1) must their instrument be able to detect? Using Equation 6–10, the concentration you have calculated, the ingestion rate of 250 mL, an exposure frequency of one day, and exposure duration of one day, an adult malebody weight, and an averaging time of 1 day, estimate the hazard index. The RfD for methyl parathion is 2.5 × 10−4 mg ・ kg−1 ・ d−1 .
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