A certain cDNA of size 2 kb hybridized to eight genomicfragments of total size 30 kb and contained two shortESTs. The ESTs were also found in two of the genomicfragments each of size 2 kb. Sketch a possible explanation for these results

Look at Figure 17-22 and state which bands are missing in the cri du chat deletion.

Describe three examples of specific recombinases that have been discussed in this class. Include a brief description for the function of each specific recombinase.

The CRISPR-Cas9 system may be able to be used for somatic gene therapy to treat terminal genetic diseases such as Duchenne Muscular Dystrophy (DMD), which affects 1 in 3,500 male births worldwide. As we talked about in class, DMD results from a nonsense mutation that causes a premature stop codon in Exon 23 of the largest gene yet discovered in the human genome, the 79- exon dystrophin gene. Of the choices below, which would be most likely to restore the protein and muscle function? O A deletion of exon 23 O A deletion of intron 23 O A deletion of intron 23 and exon 23 O An insertion of a corrected exon 23 upstream of the mutant exon 23 O A deletion of exons 23, intron 23, and exon 24