A 41-year-old man presents to the emergency department complaining of fever, chills, and malaise. A preliminary diagnosis of infective endocarditis is established, and he is started on an intravenous antibiotic administered every 6 hours. The antibiotic follows first-order kinetics and has a volume of distribution of 80 L and a clearance of 1 L/min. How much should be administered every 6 hours to maintain a therapeutic steady-state plasma concentration of 8 mg/L? A. 84 mg B. 126 mg C.1300 mg D. 1720 mg E. 2880 mg

A 65-year-old m a n with a 5-year history of alcoholic cirrhosis comes to the physician for a follow-up examination. Physical examination shows palmar erythema, gynecomastia and moderate ascites. Laboratory studies show an increased prothrombin time. Replacement of which of the following coagulation factors is most likely to improve this patient’s prothrombin time ?A) Factor VII (proconvertin)B) Factor VIII (antihemophilic factor)C) Factor IX (plasma thromboplastin component) D) Factor X (Stuart factor)E) Factor XI (plasma thromboplastin antecedent) F) Factor XII (Hageman factor)

A 56-year-old Asian man with hypertension, hypercholesterolemia, and type 2 diabetes mellitus comes to a physician for a check-up. It has been several years since he has been to the doctor. His past medical history is significant for an acute illness at the age of nine, which involved a high fever, pleuritic chest pain, migrating joint pain, and a pink, nonpruritic rash on his torso. His blood pressure is 155/100 mm Hg and heart rate is 70/min. Auscultation of the heart reveals a low-pitched diastolic rumble heard best at the apex. What is the most likely pressure change that would be seen in this patient’s heart? (A) Decreased left atrial pressure (B) Decreased left ventricular pressure (C) Increased left atrial pressure (D) Increased left ventricular pressure (E) Increased right atrial pressure

A 40-year-old woman complains of fatigue and nausea of 3 months in duration. Physical examination reveals splenomegaly and | hepatomegaly. Laboratory studies show hemoglobin of 6.3 g/dL and platelets of 50,000/mL. A peripheral smear shows malignant cells with Auer rods (arrow). The patient develops diffuse purpura, and laboratory features of disseminated intravascular | coagulation (DIC). Which of the following genes is most likely found at the translocation site in this patient? O bc-1 О тус O abl • Retinoic acid receptor

A 48-year-old woman of Mediterranean de- scent presents because of fatigue, arthralgias, discomfort in her right upper abdominal quad- rant, and polyuria. Laboratory tests are remark- able for elevated glucose level, elevated biliru- bin, low hemoglobin, elevated reticulocytes, and increased transferrin saturation. Cardiac testing shows moderate restrictive cardiomyop- athy. She frequently has required blood trans- fusions throughout her life. Which hereditary disorder does this patient most likely have? (A) Absence of the hemoglobin a-chain (B) Absence of the hemoglobin b-chain (C) Mutation resulting in increased absorption of dietary iron (D) Mutations in the gene encoding ankyrin (E) Mutations resulting in copper accumula- tion

The hyperviscosity shndrome can cause cardiac ischemia by impairing micro circulation and this syndrome is associated with erythrocytosis, leukocytes is, or hypercholesterolemi. For each condition provide a definition, indicate two causes for each condition and give the normal values.

A 35 year old woman of Chinese ethnic background (Guangdong province) presented with a near normal Haemoglobin level of 112 g/L. On performing a Full Blood Count (FBC) she was found to have an erythrocyte Mean Cell Volume (MCV) of 64.9fL and a Mean Cell Haemoglobin (MCH) value of 20.6 pg.A family study was performed on her father, mother and younger brother, including capillary electrophoresis. The following values were found:Father Mother Brother Patient Normal Range Age               74          69          32          35Hb (g/L)          98          107          113          112          133-167 (m)                                                       118-148 (f)MCV (fL)          69          89.4          62.7          64.9          80-100MCH (pg)          22.5          29.2          20.1          20.6          28-32HbA (%)          98.0          97.2          97.8          98.0          97-98HbA2 (%)          2.0          2.7          2.2          2.0          1.5-3RBC (x1012/L)…

A 2-and-a-half-year-old kid who weighed 11kg and had no previous/ known medical conditions was hospitalised for various bruises for one week owing to thrombocytopenia. Immune thrombocytopenic purpura was identified as the cause.    In light of bleeding manifestations and extremely severe thrombocytopenia with platelet level of 3 109/L, patient was suggested for two units of whole blood, derived platelet transfusion and began on intravenous immunoglobulin at a dose of 1 mg/kg. Due to the lack of blood group B platelets, the patient, who is B Rhesus D positive, got O RhD positive WB-derived platelets.    During the second unit of platelet transfusion, the kid started to experience, shortness of breath, chill, and rigor. the patient became worse with a fever of 38 C, an oxygen saturation of 80% in room air, hypotension (94/56 mmHg), tachycardia (156 beats/minute), and tachypnea (26 breaths/minute).    Blood film evidence of spherocytosis and tiny agglutinations helped to explain why the…

Based on the below blood typing result, identify the blood type

Which of the following is NOT a feature of an ideal cardiac marker? 1)  absolutely specificity 2)  ability to predict future occurrence of cardiac disease 3)  close estimation of the magnitude of cardiac damage 4)  higher sensitivity no references, just homework