A 41-year-old man presents to the emergency department complaining of fever, chills, and malaise. A preliminary diagnosis of infective endocarditis is established, and he is started on an intravenous antibiotic administered every 6 hours. The antibiotic follows first-order kinetics and has a volume of distribution of 80 L and a clearance of 1 L/min. How much should be administered every 6 hours to maintain a therapeutic steady-state plasma concentration of 8 mg/L? A. 84 mg B. 126 mg C.1300 mg D. 1720 mg E. 2880 mg
A 41-year-old man presents to the emergency department complaining of fever, chills, and malaise. A preliminary diagnosis of infective endocarditis is established, and he is started on an intravenous antibiotic administered every 6 hours. The antibiotic follows first-order kinetics and has a volume of distribution of 80 L and a clearance of 1 L/min. How much should be administered every 6 hours to maintain a therapeutic steady-state plasma concentration of 8 mg/L? A. 84 mg B. 126 mg C.1300 mg D. 1720 mg E. 2880 mg
Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
Problem 1SRQ
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A 41-year-old man presents to the emergency department complaining of fever, chills, and malaise. A preliminary diagnosis of infective endocarditis is established, and he is started on an intravenous antibiotic administered every 6 hours. The antibiotic follows first-order kinetics and has a volume of distribution of 80 L and a clearance of 1 L/min. How much should be administered every 6 hours to maintain a therapeutic steady-state plasma concentration of 8 mg/L?
A. 84 mg
B. 126 mg
C.1300 mg
D. 1720 mg
E. 2880 mg
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