A 31 g OD 21 1 OD 1 2. 31 Hospitalized Mild 0 0+ Pre-2020 control 7 28 14 21 Days since symptom onset 35 42 Figure 1. Serologic assay results for study participants with coronavirus disease (COVID-19), Atlanta, Georgia, USA, 2020. Levels of IgG against the receptor-binding domain (RBD) of the spike protein subunit S1 were analyzed for hospitalized patients with severe COVID-19 (black circles) and patients who had recovered from mild COVID- 19 (blue circles) according to time from symptom onset. Levels in pre-2020 HC participants (gray circles) are shown for comparison; dotted lines represent optimal threshold levels for receiver operating characteristic curve analysis. Best fit lines for relationships between time since symptom onset and antibody levels were calculated separately for hospitalized participants and participants with mild COVID-19. OD, optical density. From: Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020. Hu WT, et al. Emerg Infect Dis. 2020.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question

Look at the figure below. What, if anything can one conclude, and with what level of
confidence, from different antibody titers in individuals.

A
31
g
OD
21
1
OD
1
2.
31
Hospitalized
Mild
0
0+
Pre-2020 control
7
28
14
21
Days since symptom onset
35
42
Figure 1. Serologic assay results for study participants with coronavirus disease (COVID-19), Atlanta, Georgia,
USA, 2020. Levels of IgG against the receptor-binding domain (RBD) of the spike protein subunit S1 were analyzed
for hospitalized patients with severe COVID-19 (black circles) and patients who had recovered from mild COVID-
19 (blue circles) according to time from symptom onset. Levels in pre-2020 HC participants (gray circles) are shown
for comparison; dotted lines represent optimal threshold levels for receiver operating characteristic curve analysis.
Best fit lines for relationships between time since symptom onset and antibody levels were calculated separately for
hospitalized participants and participants with mild COVID-19. OD, optical density. From: Antibody Profiles
According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020. Hu WT, et al. Emerg Infect Dis.
2020.
Transcribed Image Text:A 31 g OD 21 1 OD 1 2. 31 Hospitalized Mild 0 0+ Pre-2020 control 7 28 14 21 Days since symptom onset 35 42 Figure 1. Serologic assay results for study participants with coronavirus disease (COVID-19), Atlanta, Georgia, USA, 2020. Levels of IgG against the receptor-binding domain (RBD) of the spike protein subunit S1 were analyzed for hospitalized patients with severe COVID-19 (black circles) and patients who had recovered from mild COVID- 19 (blue circles) according to time from symptom onset. Levels in pre-2020 HC participants (gray circles) are shown for comparison; dotted lines represent optimal threshold levels for receiver operating characteristic curve analysis. Best fit lines for relationships between time since symptom onset and antibody levels were calculated separately for hospitalized participants and participants with mild COVID-19. OD, optical density. From: Antibody Profiles According to Mild or Severe SARS-CoV-2 Infection, Atlanta, Georgia, USA, 2020. Hu WT, et al. Emerg Infect Dis. 2020.
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