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63 Neonatal hyperbilirubinemia is usually treated with phototherapy, resulting in prompt reduction in plasma bilirubin concentration Phototherapy is effective because of which of the following? A) Conversion of bilirubin to water-soluble isomers B) Decreased synthesis of bilirubin C) Decreased synthesis of heme D) Increased glucuronidation of bilirubin E) A switch in the excretory pathway of bilirubin

63 Neonatal hyperbilirubinemia is usually treated with phototherapy, resulting in prompt reduction in plasma bilirubin concentration Phototherapy is effective because of which of the following? A) Conversion of bilirubin to water-soluble isomers B) Decreased synthesis of bilirubin C) Decreased synthesis of heme D) Increased glucuronidation of bilirubin E) A switch in the excretory pathway of bilirubin

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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### Educational Content on Phototherapy for Neonatal Hyperbilirubinemia **Question:** Neonatal hyperbilirubinemia is usually treated with phototherapy, resulting in a prompt reduction in plasma bilirubin concentration. Phototherapy is effective because of which of the following? **Answer Choices:** A) Conversion of bilirubin to water-soluble isomers B) Decreased synthesis of bilirubin C) Decreased synthesis of heme D) Increased glucuronidation of bilirubin E) A switch in the excretory pathway of bilirubin **Explanation:** Phototherapy is a common treatment for neonatal hyperbilirubinemia. It works primarily through the conversion of bilirubin to water-soluble isomers, which are easier for the infant's body to excrete. Therefore, the correct answer is: **A) Conversion of bilirubin to water-soluble isomers** In the treatment of neonatal hyperbilirubinemia, phototherapy utilizes light to transform the structure of bilirubin in the skin. This transformation results in bilirubin isomers that are more soluble in water and, consequently, more easily excreted in the urine and bile without the need to conjugate it with glucuronic acid. **Further Explanation:** - **Option A (Correct Answer):** Phototherapy converts bilirubin to isomers that are water-soluble, facilitating excretion and lowering bilirubin levels in the plasma. - **Option B:** The synthesis of bilirubin itself is not directly decreased by phototherapy; rather, the excretion is improved by changing the bilirubin molecules. - **Option C:** Phototherapy does not reduce the synthesis of heme, which is a precursor to bilirubin. - **Option D:** While glucuronidation (the process by which bilirubin is made soluble for excretion) is important, phototherapy does not increase this process but rather bypasses the need by making bilirubin water-soluble through isomerization. - **Option E:** There is no change in the excretory pathway of bilirubin; the pathway remains the same, but the bilirubin structure is altered to be more excretable. For more detailed information on neonatal hyperbilirubinemia and phototherapy, refer to pediatric healthcare guidelines and research articles on jaundice management.
Transcribed Image Text:### Educational Content on Phototherapy for Neonatal Hyperbilirubinemia **Question:** Neonatal hyperbilirubinemia is usually treated with phototherapy, resulting in a prompt reduction in plasma bilirubin concentration. Phototherapy is effective because of which of the following? **Answer Choices:** A) Conversion of bilirubin to water-soluble isomers B) Decreased synthesis of bilirubin C) Decreased synthesis of heme D) Increased glucuronidation of bilirubin E) A switch in the excretory pathway of bilirubin **Explanation:** Phototherapy is a common treatment for neonatal hyperbilirubinemia. It works primarily through the conversion of bilirubin to water-soluble isomers, which are easier for the infant's body to excrete. Therefore, the correct answer is: **A) Conversion of bilirubin to water-soluble isomers** In the treatment of neonatal hyperbilirubinemia, phototherapy utilizes light to transform the structure of bilirubin in the skin. This transformation results in bilirubin isomers that are more soluble in water and, consequently, more easily excreted in the urine and bile without the need to conjugate it with glucuronic acid. **Further Explanation:** - **Option A (Correct Answer):** Phototherapy converts bilirubin to isomers that are water-soluble, facilitating excretion and lowering bilirubin levels in the plasma. - **Option B:** The synthesis of bilirubin itself is not directly decreased by phototherapy; rather, the excretion is improved by changing the bilirubin molecules. - **Option C:** Phototherapy does not reduce the synthesis of heme, which is a precursor to bilirubin. - **Option D:** While glucuronidation (the process by which bilirubin is made soluble for excretion) is important, phototherapy does not increase this process but rather bypasses the need by making bilirubin water-soluble through isomerization. - **Option E:** There is no change in the excretory pathway of bilirubin; the pathway remains the same, but the bilirubin structure is altered to be more excretable. For more detailed information on neonatal hyperbilirubinemia and phototherapy, refer to pediatric healthcare guidelines and research articles on jaundice management.
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