6. Retroviruses have an RNA genome instead of a DNA genome, and the RNA must be copied into the host's DNA. How does this process differ from other reactions in biochemistry? What additional steps must happen for the virus to infect a cell?

2. If you were tasked to design compounds which will prevent viral attachment and entry into a host cell, which two viral-structural features would you target and why? Capside Ene ∙es attar

75) In general DNA viruses are a. smaller than RNA viruses b. their mutation rate is higher than RNA viruses c. their replication site is mostly in the nucleus d. they depend on their viral enzymes for their replication.

1. Predict the replication step (after it has entered the host cell) for the newly discovered Opiovirus. It has a dsDNA genome. • Draw out your prediction. Include any proteins/enzymes the virus will need to use, bring, or express to carry out the replication. Indicate where it is likely for replication to occur in the host cell.

2. Predict the replication step for the novel Miovirus. This virus was determined to have a dsRNA genome Draw out your prediction. Include any proteins/enzymes the virus will need to use, bring or express to carry out the replication. Indicate where it is likely for replication to occur in the host cell.

1. If you knew the amino acid sequence of a peptide could you use that information to find the gene in a pool of genomic DNA. If so, how might you do this. 2. What is the difference between lytic and lysogenic viral replication?

6. List the main similarities and differences between transposons, retrotransposons, group II introns, and retroviruses. Transposons Retrotransposons Group II introns Retroviruses

3. Why is it more difficult to develop an antiviral drug than an antibiotic? Think selectively toxic targets.  What is a virus made of?  Why can’t we target DNA/RNA/Protein?