5) Humans who have an abnormally high level of cholesterol are said to suffer from familial hypercholesterolemia. The gene for this disorder is dominant (C). A man who is heterozygous for familial hypercholesterolemia marries a woman who is homozygous for the recessive allele. What is the probability that they will have children that suffer from this disorder? please draw the puutnet square and also write the parents and gemtaics top the puutnet square thanks
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5) Humans who have an abnormally high level of cholesterol are said to suffer from familial
hypercholesterolemia.
The gene for this disorder is dominant (C). A man who is
heterozygous for familial hypercholesterolemia marries a woman who is homozygous
for the recessive allele. What is the probability that they will have children that suffer
from this disorder? please draw the puutnet square and also write the parents and gemtaics top the puutnet square thanks
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Solved in 2 steps
- a) Identify and describe 5 different types of genetic inheritance.(b) In humans, glucose-6-phosphate dehydrogenase deficiency is a recessive X-linkedtrait. Describe the inheritance of this disease, including an example of the possibleoutcomes of:(i) An affected mother and an unaffected father having children. (ii) An affected father and a homozygous unaffected mother having childrenIn individuals affected by cystic fibrosis, salt crystals may appear afterperspiration dries up. In addition, the disease causes respiratory disorderswhich can be both debilitating and lethal. It occurs in individuals homozygousfor the recessive gene. Two normal parents had a daughter with thesymptoms of this disease, and a normal son who marries a normal womanwith an afflicted A test (salt concentration in perspiration of heterozygotes ishigher than normal) disclosed that both are indeed carriers of the gene. If thefirst child born to the mating in (b) was defective, what is the probability thatthe 2nd child would also be defective?Express answer in fraction formA young couple went to see a genetic counselor because each had a sibling with cystic fibrosis. (Cysticfibrosis is a recessive disease, and neither member ofthe couple nor any of their four parents is affected.)a. What is the probability that the female of thiscouple is a carrier?b. What are the chances that their child will havecystic fibrosis?c. What is the probability that their child will be acarrier of the cystic fibrosis disease allele?
- Cystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of stickymucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helpedthe afflicted to live through adulthood.The mother of Claudia died from cystic fibrosis, but her father was normal and never had anyrelative with CF. Her fiancé, Marcus, turned out to be a carrier of the CF allele. What are the genotypes of Claudia and Marcus? Claudia: ________________________ Marcus: _____________________ They planned to have four children. What is the probability that: a. all children will be normal b. at least two will be normal1a) Explain how amino acids in casein could reach the liver, starting fromthe moment when the person takes a bite of pastry cream pie. b) Congenital lactase deficiency is a type of lactose intolerance that occursin infants. It is inherited in an autosomal recessive pattern. Calculate thechance of congenital lactose intolerance in a child whose parents are both carriersfor the disorder, showing fully how you reached your answer.One form of the bleeding disorder known as von Willebrand disease is an autosomal recessive disease. A man who is a carrier marries a woman who is also a carrier of the disease. (a) What percentage of their children are likely to have a disease phenotype? (b) What percentage of their children are likely to have a normal phenotype? (c) What percentage of their children are likely to be carriers of the disease?
- Cystic fibrosis (CF) is an autosomal recessive condition triggered by the overproduction of stickymucus that clogs the lungs and pancreas. It is a life-threatening disease, but medical advances helpedthe afflicted to live through adulthood. The mother of Claudia died from cystic fibrosis, but her father was normal and never had anyrelative with CF. Her fiancé, Marcus, turned out to be a carrier of the CF allele. What are the genotypes of Claudia and Marcus? Claudia: ________________________ Marcus: _____________________ They planned to have four children. What is the probability that:a. all children will be normal b. at least two will be normalCystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF. a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF? b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected? c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?Duchenne muscular dystrophy is sex linked and usuallyaffects only males. Victims of the disease become progressively weaker, starting early in life.a. What is the probability that a woman whose brotherhas Duchenne’s disease will have an affected child?b. If your mother’s brother (your uncle) had Duchenne’sdisease, what is the probability that you have receivedthe allele?c. If your father’s brother had the disease, what is theprobability that you have received the allele?
- In 1995, doctors reported a Chinese family in whichretinitis pigmentosa (progressive degeneration of theretina leading to blindness) affected only males. Allsix sons of affected males were affected, but all of thefive daughters of affected males (and all of thechildren of these daughters) were unaffected.a. What is the likelihood that this form of retinitispigmentosa is due to an autosomal mutationshowing complete dominance?b. What other possibilities could explain the inheritance of retinitis pigmentosa in this family? Whichof these possibilities do you think is most likely?Hypophoshatemia is a dominant genetic disorder caused by deficiency of pho[hates in the blood. Assuming the other parent is free of the disorder, males with the disorder will pass it on to all their daughters but not their sons. Females with the disorder will pass it on to approximately half of their children. a.) Is this pattern of inheritance autosomal or sex-linked? Explain b.) Draw a Punnett square to show the inheritance pattern of the disorder in each of the two scenariosSickle cell anemia is inherited as an autosomal recessive condition. It also exhibits incomplete dominance in that the heterozygous genotype displays a mild form of the disease known as sickle cell trait while individuals with the homozygous recessive genotype have a severe form of SCA. A man who has severe sickle cell anemia marries a woman who suffers from a mild trait. What is the probabilitu they will have a child with severe SCA?What is the probability they will have a child with mild SCA? What is the probability they will have a normal child? Show ALL work using punnett squares.