5-Bromouracil (BU) resembles thymine sufficiently that BU base-pairs readily with adenine in a DNA helix, and it can readily substitute for thy- mine in DNA replication. However, its electron distribution allows it to resemble cytosine sufficiently that BU can pair with guanine. Show how a few rounds of replication in the presence of BU could convert an A-T base pair to G-C, and identify the products of each round of replication.

5-Bromouracil (BU) resembles thymine sufficiently that BU base-pairs readily with adenine in a DNA helix, and it can readily substitute for thy- mine in DNA replication. However, its electron distribution allows it to resemble cytosine sufficiently that BU can pair with guanine. Show how a few rounds of replication in the presence of BU could convert an A-T base pair to G-C, and identify the products of each round of replication.

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter23: Enzymes

Section: Chapter Questions

Problem 23.90P

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