ерохide hydrolase P450 HO Но Benzo[a]pyrene ВP 7,8-ерохide BP 7,8-dihydrodiol P450 `NH `NH HO. DNA ... Но HO OH OH BP 7,8-dihydrodiol-9,10-epoxide (BPDE) BPDE-deoxyguanosine adduct
Coding Strand of DNA
When pointing to DNA transcription, the coding strand is found to be the DNA strand whose base sequence is indistinguishable from the base sequence of the RNA transcript developed. It is this strand that comprises the codons, while the non-coding strand comprises the anti-codons.
Nucleotide
Both DNA and RNA are composed of organic molecules known as nucleotides. Hence, nucleotides are known as the basic building blocks of nucleic acids. These substances play a role in various processes such as cell signalling, enzyme reactions, metabolism, and so on.
Structure of Cytosine
Cytosine is among the five primary nitrogenous bases of which DNA and RNA and are being used in storage and transportation of genetic makeup within a cell. Adenine, guanine, thymine as well as uracil are the remaining four nucleobases.
Of the four DNA bases, why is guanine most likely to be modified after exposure to polycyclic hydrocarbons such as benzo(a)pyrene, as shown in Figure ? (Hint: Consider the pKa values of the four DNA bases.)
![ерохide
hydrolase
P450
HO
Но
Benzo[a]pyrene
ВP 7,8-ерохide
BP 7,8-dihydrodiol
P450
`NH
`NH
HO.
DNA
...
Но
HO
OH
OH
BP 7,8-dihydrodiol-9,10-epoxide
(BPDE)
BPDE-deoxyguanosine adduct](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F9d7a53a4-273d-4dc1-8363-52196c611287%2Fe4f813cf-c16d-4b5e-a7c4-c526d0eecefb%2Fjmhdwuq_processed.png&w=3840&q=75)
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