4. Multiple Alleles: ABO Blood Types a. Indicate the expected genotype and phenotype ratios for these pairings: i. I^IB x ii Genotype ratio: Phenotype ratio: ii. I^i x I Bi Genotype ratio: Phenotype ratio:

2. Describe the phenotype of the cats with these genotypes (If allele not specified, assume wild type): CC ss OO BB dd McMc tt ww Light brown male with choco [Choose ] Light brown male with chocolate tips ctct ss OY bb TAt A uniformly colored black cat Light grey female with dark grey mackerel stripes Black female with large white patches Dark grey with black mackerel stripes Cc SS Oo BB TATA Cream male with small white patches and orange mackerel stripes CC Ss oY bb dd tt [Choose ]

d Dd 501. s0% 5. Another type of blood disorder is hemophilia, which is an X linked disorder caused by a recessive allele. Like VWD, this disorder interferes with the protein that is involved with blood clotting. Known as "bleeder's disease" because any minor injury can become life threatening. This disorder is considered more severe than VWD. In both cases there are versions of the disorder that can be less and more severe depending on which protein or clotting factor is affected. Normal XHY Normal X"Xh Carrier XhY Hemophilia Bourthelesm X"Xh Hemophilia If a woman is a carrier, what percentage of her SONS will have the disorder? How many (%) of their sons will have hemophilia? How many (%) of their sons will be normal? How many (%) of their daughters will be normal? 6. A man who has hemophilia marries a normal woman (not a carrier)... How many (%) of their sons will have hemophilia? How many (%) of their daughters will be carriers 7. A woman who is a carrier marries a man with…

3. What are the genotypes possible for a person who has: A blood? B blood? O blood? AB blood? 4. A man with type AB blood is married to a woman also with type AB blood. Show the cross. What proportion of their children will have: A blood? B blood? O blood? AB blood? 5. A man has type B blood (genotype I³I®) is married to a woman with type O (ii) blood. Show the cross. What proportion of their children will have: 1. A blood? 2. B blood? 3. O blood? 4. AB blood? 6. A woman with type A blood (genotype I^i) is married to a type B person (genotype Iºi). Show the cross. What proportion of their children will have: A blood? B blood? О blood? AB blood?

16.A couple is suspecting that their baby was switched at the hospital. The mother has blood type A, the father has blood type B, and the baby has blood type O. Which among the following conditions would prove that the baby is switched? A. Mother’s genotype: IAIA & Father’s genotype: ii B. Mother’s genotype: ii & Father’s genotype: IBIB C. Mother’s genotype: IAIA & Father’s genotype: IBIB D. Mother’s genotype: IAi & Father’s genotype: IBi

A. For the following genotypes state the ABO blood phenotype. JAJA |B|O_ 101⁰_ |A|B_ B. Using genetic diagrams, show how it is possible for a couple with a type A mother and a type B father can have a child with type O blood. C. Using genetic diagrams show how a type AB person with a type O partner have offspring that share neither of their phenotypes.

Date Name Punnett Square Practice Worksheet 1) For each of the genotypes (AA, Aa or aa) below determine what the phenotype would be. Purple flowers are dominant to white flowers. PP Pp PP Hairy knuckies are dominant to non-hairy knuckles in humans. Hh hh HH Bobtails in cats are recessive. Normal tails are dominant. Tt tt TT 2) For each of the following write whether it is homozygous dominant, heterozygous or homozygous recessive. AA gg Pp Ii TT Use the following information for questions 3-5: In dogs, the gene for fur color has two alleles. The dominant allele (F) codes for grey fur and the recessive allele (f) codes for black fur. 3) The female dog is heterozygous. The male dog is homozygous recessive. Figure out the percentage or ratio of possible phenotypes and genotypes of their puppies by using a Punnett Square. Plae the oileles for the mule parent helm One alele n e h lie: % of possible Genotypes: FF Plar the alfele f he emle p r ti side One elleir on ch tine Ff: % of possible…

2. Show the possible alleles that can be found in each offspring and write the blood type for each offspring Possible alleles from Father A B 0 Possible alleles Mother from A B O Using punnet square

3. What is the genotypic ratio of the test cross shown in Figure 4?

V. Two Gene Pairs (Extra Credit) 1... A. In peas, the allele for tall plants (T) is dominant over the allele for short plants (t). The allele for smooth peas (S) is dominant over the allele for wrinkled peas (s). Use this information to cross the following parents. I 1. heterozygous tall and smooth X heterozygous tall and smooth 2. heterozygous tall, wrinkled X short, wrinkled AL.