(22) A 35- year old woman and her 35-year old husband come to the physician for genetic counselling after their son is diagnosed with a rare metabolic disease. The carrier frequency of this disorder in the general population is 1 of 100. Assuming Hardy-Weinberg equilibrum, which of the following bst represents the

In this fictitious example of a cohort study, we found that in a factory of 3,000 workers, 1,000 workers were exposed to toxic substances, and 2,000 were not. During the study period, 800 of the exposed workers developed some type of lung disease, and only 40 of the non-exposed workers developed a lung disease. A. What is the incidence of lung disease among exposed workers? Use 1,000 as the multiplication factor and answer should be in whole numbers. B. What is the incidence of lung disease among non-exposed workers? Use 1,000 as the multiplication factor and answer should be in whole numbers.

Genotypes of leopard frogs from a population in central Kansas were determined for a locus (M) that encodes the enzyme malate dehydrogenase. The following numbers of genotypes were observed:   Calculate the genotypic and allelic frequencies for the population (round to the nearest thousandth). f(M1M1) = f(M1M2) = f(M2M2) = f(M1M3) = f(M2M3) = f(M3M3) = f(M1) = f(M2) = f(M3) =   What would be the expected number of each genotype (round to the nearest whole number assuming genotype represents an individual) assuming the population was in Hardy Weinberg equilibrium? f(M1M1) = f(M1M2) = f(M2M2) = f(M1M3) = f(M2M3) = f(M3M3) =    Referencing a p-value of 0.05 and a CV of 11.070, state if the population is in HWE. Genotype Observed Expected O–E (O–E)2 (O–E)2/E M1M1           M1M2           M2M2           M1M3           M2M3           M3M3             Chi-squared = Statement:…

In a population of weasels, there are 100 individuals with genotype AA, 150 individuals with genotype Aa, and 50 individuals with genotype aa. What is the value of Fst?(recall: Fst = 1 - (Ho / He)). a) 0.25 b) 0.33 c) 0.4 d) 0.5

Human blood type is determined by three alleles, IA, IB, and IO. The alleles IA and IB are co-dominant to each other, and both are dominant to IO. These alleles combine to produce four phenotypes: type A, type B, type AB, and type O. Within a large, randomly mating population (540,000 individuals), the frequencies for the blood type alleles are 0.3 for the IA allele, 0.6 for the IO allele, and 0.1 for the IB allele. Calculate the expected numbers of people in the population having each of the blood types A, B, AB, and O. A. A = 48,600 people B = 5,400 people AB = 32,400 people O = 194,400 people   B. A = 243,000 people B = 5,400 people AB = 32,400 people O = 194,400 people   C. A = 162,000 people B = 54,000 people AB = 3,240 people O = 324,000 people   D. A = 194,400 people B = 64,800 people AB = 32,400 people O = 194,400 people   E. A = 243,000 people B = 70,200 people AB = 32,400 people O = 194,400 people

In 1998, Sally Clark was tried for murder after two of her sons died shortly after birth. During the trial, an expert witness for the prosecution testified that the probability of a newborn dying of sudden infant death syndrome (SIDS) was 1/8500, so the probability of two deaths due to SIDS in one family was (1/8500)7, or about one in 73 million. Therefore, he continued, the probability of Clark's innocence was one in 73 million. What is wrong with the prosecution's reasoning?

The mean weight of loaves of bread produced at the bakery where you work is supposed to be 1 pound. You are the supervisor of quality control at the bakery, and you are concerned that new employees are producing loaves that are too light. Suppose you weigh an SRS of bread loaves and find that the mean weight is 0.975 pound. What are the appropriate hypotheses for performing this significance test? Ho : x = 1; H. : x < 1 where i = the sample mean weight (in pounds) of bread loaves produced at the bakery. Ho : u = 1; H. : µ < 1 where u = the true mean weight (in pounds) of bread loaves produced at the bakery. Ho : µ < 1; H, : H = 1 where u = the true mean weight (in pounds) of bread loaves produced at the bakery. Ho : u = 1; H. : p = 0.975 where u= the true mean weight (in pounds) of bread loaves produced at the bakery. Ho : u = 1; H. : u # 1 where u= the true mean weight (in pounds) of bread loaves produced at the bakery.

“Calculate the rates specified below (a to c), using the following information about the black population of the United States in 2000 (numbers were modified to simplify calculations) “( be careful to use the correct denominator)   Average population size 28 million, including 7.2 million women aged 15-44. There were 13 million men in this population. Live births: 600,000 Fetal deaths: 4380 Death in the first week of life: 6120 Death in the first 28 days of life (excluded first week): 960 Death in the first year of life (excluding in the first 28 days): 3900 Total deaths in the population: 230,000 Deaths from heart diseases: 75,000, of those 45,000 occurred among men aged 35 years and above     What is the fetal mortality rate? What is post-neonatal mortality rate? What is the sex -specific mortality rate from heart disease

17) In chi-squared analysis... A. If the observed data exactly agree with the predictions of the hypothesis, then we expect the p-value to be               (1.0, 100, less than 0.05, 0, greater than 0.05)           B. If the observed data closely agree with the predictions of the hypothesis, then we expect the p-value to be       (1.0, 100, less than 0.05, 0, greater than 0.05)         C. If the observed data do not at all agree with the predictions of the hypothesis, then we expect the p-value to be (1.0, 100, less than 0.05, 0, greater than 0.05)           Chose one from the parenthesis for each question.

a.)If the frequency of an allele at a locus of interest is 0.57, what is the frequency of the genotype that is homozygous for this allele (that is, that genotype has two copies of this allele)? b.) If we know that the frequency of an allele at a locus of interest is 0.57, we have enough information to calculate the frequency of the related phenotypes in the population, assuming there are only two alleles.