2. The common grandfather of two first cousins has hereditary hemochromatosis, a recessive condition causing an abnormal buildup of iron in the body. Neither ofthe cousins has the disease nor do any of their relatives.a. If the first cousins had a child, what is the chancethat the child would have hemochromatosis?Assume that the unrelated, unaffected parents ofthe cousins are not carriers.b. How would your calculation change if you knewthat 1 out of every 10 unaffected people in the population (including the unrelated parents of thesecousins) was a carrier for hemochromatosis?

4. Mr. Salazar has Type A blood while Mrs. Salazar has Type B. They have four children. Bobbie has Type A, Gabbie has Type B, Alex has Type AB, and Teddie has Type O. What are the genotypes of all six people in this family? NOTE: The ABO blood type gene has three alleles. IA and IB are codominant; i (for Type O) is recessive to both.

7. Instead of one big square it is much easier to make two small Punnett squares, one for each gene. In the space at the bottom of page, draw the two squares (from 4d and 5b on previous page). Indicate the phenotypic ratios for each square and then multiply to get the combined probabilities. For example, the probability of having both diseases requires multiplying the probability of each event. a. Is the inheritance of an "A" or "a" allele dependent on (or affected by) the inheritance of a "B" or b" allele? Why or why not? (hint: Which of Mendel's Laws is involved?) b. What is the chance that their child will be phenotypically normal (for both genes)? Show your work: c. What is the chance that their child will be genotype aabb (affected with both diseases)? Show your work: d. What is the chance that they will have a boy who has genotype AaBb (carrier for both diseases like his parents)? Show your work:

22. Which of the below pedigrees best depicts the inheritance pattern of sickle cell anemia? Explain your choice ( . Note: square= male; circle = female; shaded in = affected healthy A. C. CHO p 399 O D. T DO On

9. (4) Sickle cell anemia is an autosomal recessive disorder. If the frequency of sickle cell anemia in Hispanic Americans is 1 in 16,300 and the population is mating randomly for the sickle cell gene, what proportion of the Hispanic American population consists of heterozygous carriers of the CF allele?