Marfan syndrome is a genetic trait caused by in a dominant allele. The trait causes a weakening of the aorta that can be fatal. A teenager whose mother has the syndrome (but whose maternal grandfather was not affected), and whose father was unaffected, is concerend that she may have the trait. a. What is the phenotype of each of her parents? Genotype? b. What is the chance that the teenager has Marfan syndrome?

12. Genetic disorders can be studied using the construction of pedigrees. In a pedigree: a. Males are represented by: b. Females are represented by: c. Affected individuals are represented by:

1.ABO blood groups, an autosomal trait, in Humans are genetically determined. A woman with type O blood has a son with type O.

4. A man with type O blood is married to a woman with type AB blood. They have two children together and one adopted child. Allie has type A blood, Ben has type B blood, and Oscar has type O blood. Which child was adopted? Explain your answer: 0abbocDd 6 AebbCoDo

7. The following antigens are present: D, c, E, and e. Determine the possible genotypes. (hint: there are 2 possibilities). 8. The following antigens are present: D, c, e. Determine the possible genotypes. (hint: there are 2 possibilities). The following antigens are present: D, c, E. Determine the possible genotypes. (hint: there are 2 possibilities). 9.

1. Red-green colorblindness is caused by a recessive allele (x) at an X-linked gene, and albinism is caused by a recessive allele (a) at an autosomal gene. A phenotypically normal woman (Sara) has a father who is colorblind, and she knows that she is a carrier for albinism. She plans to have a child with a colorblind man (Abdul) who is also a carrier for albinism. What is the probability that Sara and Abdul's child will have one of the conditions, but not both? (C. Follow the steps below to answer this question. a) What is the cross? b) What are the target genotypes? Note: it might be useful to come back to this one and double- check it after you have completed step c, below. Break this down to the single gene level by answering the following questions: a. What is the proportion of normal to albino offspring? Show the Punnett square: b. What is the proportion of normal to colorblind offspring? Show the Punnett square: d) What is the probability that Sara and Abdul's child will have one…

4. A man and woman marry and have 3 children. When the man is 50 years old, he is diagnosed with Huntington's disease (which is inherited dominantly). The woman is tested and she does not carry the gene. What is the chance for each child to have Huntington's disease? Are the 3 events (the children having HD) independent or mutually exclusive? What are the chances that all three children are HD free? If one of the three children marries a person with no family history of HD (assume normal), what is the chance that their child will have the disease? (we do not know yet if the parent has it or not)

7. In order to display an autosomal recessive phenotype, the individual must be 1. Homozygous dominant 2. Homozygous recessive 3. Heterozygous

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30. Hemophilia is an X-linked recessive trait. Which of the following represents a hemophiliac female?   1. XAXA 2. XaY 3. aa 4. XaXa