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- 1. Which of the following amines would make an imine if reacted with an aldehyde or ketone? A B e. Which of the following moleculo C NH₂ AN DWhich of the following functional groups will react faster and at lower conditions to a nucleophilic attack? (you can think of a nucleophilic attack by an amine). O a. Carboxylic Acid o b. Nitrile о с. Асyl Нalide d. Ester3. For the following amines, propose a stepwise synthesis for each compound. ? NH2 a) он ? b) ZI
- 4. Please give the starting materials that would be necessary to make the following imines and enamines. a C d N. N atArrange the following compounds in INCREASING reactivity towards Nucleophilic Acyl Substitution. ABC O Jh Br O DEF INCREASING REACTIVITY: choose your answer... NH₂ GHI choose your answer... OH < choose your answer...a. What is the amine and coupling components of this azodye? H;CO- -N=N-
- Give the major product for the reaction. Pyrrolidine is a secondary amine. CH CH O CH CH! O OH CH2 O CH. I CH.CH Ї TCH CHE OH CH CH₂CH₂ CH.CH CH.OH2 0= RO pyrrolidine. 2 GH CH2 3 HCI H,0 TOH OH: CH₂CH₂ TCH CH: CH₂CH. CH₂CH₂a. Write the mechanism for the following reactions:1. the acid-catalyzed hydrolysis of an imine to a carbonyl compound and a primary amine2. the acid-catalyzed hydrolysis of an enamine to a carbonyl compound and a secondary amine b. How do the two mechanisms differ?Draw the major product formed by treating each amine with excess CH3I, followed by Ag,0, and then heat. -CH,CHCH3 NH2 а. b. C. H2N
- C. Arrange the following compounds in order of decreasing reactivity towards hydrolysis. H2N. H,CO NAI IYK КАН BCS1.answer the following questions A. What is reagent used to convert secondary amine to tertiary amine? choices: NH3,SOCL2,H20 and excess NH3,Methylhalide? B. During azide synthesis what is good leaving group? Choices: N3,N2,H20,NH2C. Arrange the following compounds in order of decreasing reactivity towards hydrolysis. H2N .CI H3CO NAI IYK КАН BCS
