Chemistry
Chemistry
10th Edition
ISBN: 9781305957404
Author: Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher: Cengage Learning
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1. The half-life of perfluorooctanoic acid (PFOA) in female humans is
approximately 3.8 years. If the concentration in the adipose tissue of a
woman is 136 ng/g, how long would it take for the level to drop to 10
ng/g (assuming no further exposure occurs).
2. A drug appears to follow first-order elimination kinetics. If the
plasma concentration following complete absorption of an oral dose is
65 µg/L and 4 hours later it is 25 µg/L, calculate the elimination half-
life of the drug.
3. Plasma concentrations following a dose of a drug are shown below.
Calculate the elimination rate constant for the agent based on these
data. (Hint: create a plot using Excel and see if you can determine a
value for a slope.)
time (hours) concentration (ng/ml)
16
62
75
58
47
36
27
20
15
8.5
4.5
2.5
0.5
1
2
3
4
6
8
10
12
16
20
24
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Transcribed Image Text:1. The half-life of perfluorooctanoic acid (PFOA) in female humans is approximately 3.8 years. If the concentration in the adipose tissue of a woman is 136 ng/g, how long would it take for the level to drop to 10 ng/g (assuming no further exposure occurs). 2. A drug appears to follow first-order elimination kinetics. If the plasma concentration following complete absorption of an oral dose is 65 µg/L and 4 hours later it is 25 µg/L, calculate the elimination half- life of the drug. 3. Plasma concentrations following a dose of a drug are shown below. Calculate the elimination rate constant for the agent based on these data. (Hint: create a plot using Excel and see if you can determine a value for a slope.) time (hours) concentration (ng/ml) 16 62 75 58 47 36 27 20 15 8.5 4.5 2.5 0.5 1 2 3 4 6 8 10 12 16 20 24
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