Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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1. For a single locus with two alleles, A₁ and A₂:
(a) Draw a graph (using graph paper) showing both the frequency of A₁ A2 heterozy-
gotes and A₂ A₂ homozygotes, at Hardy-Weinberg frequencies, as functions of p
(the frequency of A₁). Note that both p and the genotype frequencies should have
values between 0 and 1.
(b) Find the value of p above which A₁ A2 genotypes are more common than A₂42
genotypes. You can solve this algebraically, or estimate it from your graphs.
2. Consider three loci, A, B, and C, each with two alleles, with the frequencies of A₁, B₁,
and C₁ all being
We look at a population and find that there are four distinct haplotypes, shown here,
each with a frequency of:
A₁
B1
TT
A1
C₁
B1
A₂ B₂
AT
C₂
A₂ B₂ C₁
C₂
Of the three pairs of loci (AB, AC, and BC) which pair(s) are in Gametic Equilibrium
(D = 0) and which are in Gametic Disequilibrium (D ‡0)?
[Hint: Consider each pair separately, ignoring the other locus. For example: for the BC
pair, consider the four combinations shown (B₁C₁, B₁C2, B₂C₁, and B₂C₂) ignoring
the A locus.]
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Transcribed Image Text:1. For a single locus with two alleles, A₁ and A₂: (a) Draw a graph (using graph paper) showing both the frequency of A₁ A2 heterozy- gotes and A₂ A₂ homozygotes, at Hardy-Weinberg frequencies, as functions of p (the frequency of A₁). Note that both p and the genotype frequencies should have values between 0 and 1. (b) Find the value of p above which A₁ A2 genotypes are more common than A₂42 genotypes. You can solve this algebraically, or estimate it from your graphs. 2. Consider three loci, A, B, and C, each with two alleles, with the frequencies of A₁, B₁, and C₁ all being We look at a population and find that there are four distinct haplotypes, shown here, each with a frequency of: A₁ B1 TT A1 C₁ B1 A₂ B₂ AT C₂ A₂ B₂ C₁ C₂ Of the three pairs of loci (AB, AC, and BC) which pair(s) are in Gametic Equilibrium (D = 0) and which are in Gametic Disequilibrium (D ‡0)? [Hint: Consider each pair separately, ignoring the other locus. For example: for the BC pair, consider the four combinations shown (B₁C₁, B₁C2, B₂C₁, and B₂C₂) ignoring the A locus.]
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