Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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1. A mutation in the gene that encodes for the histone acetyl transferase that would acetylate histones: Chromatin Remodeling
how this might impact gene expression specifically!
2. A mutation in the binding site of an enhancer region which prevents a regulatory protein from binding: Regulatory Regions (Transcriptional Control)
how this might impact gene expression specifically!
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- Gene Regulation and Breast Cancer Researchers have found that breast cancer cells commonly express a transcription factor known as Ets1 at high levels. Many types of breast cancer are also sensitive to the presence of the hormone estrogen. In estrogen-sensitive breast cancers, tumors grow much more quickly when high levels of estrogen are present. A biologist decides to design an experiment to determine if there was any cooperation between estrogen and Ets1in causing tumor growth. The biologist developed two types of breast cancer cells: one that expressed Ets1 at very high levels, designated as Ets+, and one that was unable to express Ets1, designated as Ets–. The biologist used four test groups in an experiment: 1. Ets1+ cells with added estrogen 2. Ets1- cells with added estrogen 3. Ets1+ cells without estrogen 4. Ets1- cells without estrogen The growth rate of each group of cells was monitored and recorded. Use the passage to answer the question. After five days of cell…arrow_forwardGene expression in mammals can be increased by which of the following mechanisms? X-chromosome inactivation (as in the case of the female tortoiseshell cat) histone demethylation histone methylation histone deacetylation histone dephosphorylationarrow_forwardPlease answer question 10arrow_forward
- Please helparrow_forwardTrans-acting regulators of gene expression include? (Select all that apply) Question 6 options: Introns Activators UAS Promoters Start codons Enhancers Histone deacetylases Silencers The TATA box Insulator sequencesarrow_forward3. miR164 is a gene that encodes for a miRNA that targets a transcription factor. Describe in detail how, mechanistically, expression of miR164 could lead to altering the function of the transcription factorarrow_forward
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