1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase

1 Unoccupied receptor does not interact with G, protein. Extra- collular space -Hormone or neuro- transmitter Cell membrane Gs protein with bound GDP Synaptic signaling Receptor Target cell Inactive adenylyl Cytosol GOP cyclase Nerve cell Occupied receptor changes 2 shape and interacts with a subunit of G, protein. G, protein releases GDP and binds GTP. Neurotransmitter Endocrine signaling Hormone Inactive adenylyl cyclase GTP Target cell GDP a Subunit of G, protein 3 dissociates from By and Blood vessel activates adenylyl cyclase. Active adenylyl cyclase Direct contact АТР Gap junction GTP CAMP + PP When hormone is no longer 4 present, the receptor reverts to resting state. GTP on the a subunít is hydrolyzed to GDP, a rejoins By, and adenylyl cyclase is deactivated. Signaling cell Target cells Inactive adenylyl cyclase

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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