1) Describe in detail the process of synaptic transmission at the neuromuscular junction.

Describe the position where wrist and finger are in full extension.  What sensation will be felt in this position? What explains this sensation that you felt when the wrist and fingers were positioned in extension? *NOTE: Apply any of the following concepts to the explanation as deemed appropriate and connected to the situation above: Mucle Contraction, Concentric Contraction, Isometric Contraction, Eccentric Contraction, Force Velocity Curve, Stretch Reflex, Reciprocal Inhibition, Autogenic Inhibition, Length-Tension Relationship

When an action potential arrives at the neuromuscular junction, acetylcholine is released into the synaptic cleft and binds to receptors in the postsynaptic membrane. Which of the following represents the correct order of the next series of events?   A. An action potential travels down the T tubules, depolarization spreads through the T tubules, Ca2+ is released from the sarcoplasmic reticulum, and myosin binds to actin.   B. Ca2+ is released from the sarcoplasmic reticulum, an action potential travels down the T tubules, depolarization spreads through the T tubules, and myosin binds to actin.   C. An action potential travels down the T tubules, depolarization spreads through the T tubules, Ca2+ is taken up by the sarcoplasmic reticulum, and myosin binds to actin.   D. T tubules are depolarized, Ca2+ is released from the sarcoplasmic reticulum, an action potential is created in the muscle cell, and myosin bonds to actin.   E. An action potential travels…

33) which of the following is released into the synaptic cleft and is responsible for depolarizing the sarcolemma? a) tropomyosin b) acetylcholine  c) troponin  d) cal

We've referred to alpha-motor neurons as the "decision making centre" for whether or not a muscle fibre contracts. Which of the following statements are true with regards to his concept? Select all that apply. O Alpha motor neurons receive input from many different sources, the balance of which determines whether or not the alpha-motor neuron fires an action potential O Alpha motor neurons are involved in conscious decision making in our central nervous system for planning and executing movements O When an action potential is initiated in an alpha-motor neuron, we are guaranteed an action potential in the muscle fibre, and hence contraction of that fibre. This means the muscle itself does not determine whether or not it contracts O Alpha motor neurons report information on where we are in space (proprioception) back to the central nervous system

what are the events that occurs when the calcium channel is blocked in neuromuscular junction?

2) Paula is a scientist who is developing a drug called Fremtol that will be used to treat muscle spasms. This drug acts on specific skeletal muscles to (1) block the release of Ca2+ ions from the sarcoplasmic reticulum, (2) inhibit the pivoting ability of the myosin heads of the thick filaments, and (3) block the production of ATP by the mitochondria in skeletal muscles. By using this drug, contraction of certain skeletal muscle fibers is reduced, which keeps those muscles from producing spasms. In the above scenario, Fremtol’s effect of blocking the release of Ca2+ ions from the sarcoplasmic reticulum would most directly prevent which the following? a. activation of tropomyosin b. activation of troponin c. activation of actin d. All of the above e. None of the above

How do we know that there are vesicles filled with neurotransmitters at the neuromuscular junction? Why are they termed ‘quanta’?

Describe in detail the events at the neuromuscular junction and how these events allow for the excitation-contraction coupling event to occur.  Be sure to also include in detail all the steps at the NMJ and the steps of the excitation-contraction coupling event, including the cross bridge cycle.