Refer back to figure 13.5. The numbers 1-4 indicate the chain of events that occur at the neuromuscular junction.  Put these events in chronological order.

Riluzole is a licensed drug for motoneuron disease. When prescribed, it extends the life expectancy of patients by approximately how long?

You are a brilliant (but evil) biochemist who is developing a toxin that can be used to paralyze skeletal muscle. Using your knowledge of the sequence of cellular/molecular events that cause a muscle contraction, identify two parts of the process that could be disrupted to cause paralysis, and explain the specific effect of each disruption on contraction. please help

Researchers are working to understand a rare disease that affects the ability of the muscles to contract. They have identified that the disease is caused by abnormal gene expression leading to a relatively large intracellular space between the T-tubules and the terminal cisternae in the triad, which causes an interruption in the connection between the dihydropyridine (DHP) receptor and the ryanodine calcium channel. Based on this description of the morphology underlying the disease, which of the following problems would you expect in excitation-contraction coupling? An action potential would not be able to be transmitted down the T-tubule. Re-uptake of calcium would be blocked, leading to an increase in intracellular calcium. O The actin binding sites may continue to be blocked by tropomyosin even following an action potential along the sarcolemma. O All of the above. Only B and C.

explain Centromeric constriction

Can you match the sacromere anatomy with the proper answer from the list below the table graph? Sarcomere Anatomy Description/Reaction Thin Filaments ? Thick Filaments  ? A Band  ? I Band ? M Line ? H Zone ? Z Disc ? A) G-Actin, F-Actin, Troponin, Tropomyosin B) Myosin C) Bisected by the M Line, this area shows only the thick filaments without any thin filamentous overlap D) The point of origin for myosin filaments found in the center of the sarcomere E) An area in the center of the sarcomere marked by the entire length of the thick filaments F) A space between sarcomeres with the z-disc in the center; this region shows Actin's anchorage points and extension without myosin overlap G) Anchoring point for the thin filaments

The cell in the center of the electron micrograph above is important in wound healing and plays a role in the pathological process underlying Dupuytren's contracture. Which of the following cell types is depicted? A. Endothelial cell B. Myoepithelial cell C. Myofibroblast D. Pericyte E. Smooth muscle cell

How do we know that there are vesicles filled with neurotransmitters at the neuromuscular junction? Why are they termed ‘quanta’?

How does the brain initiate a muscle contraction? Please order the steps that occur at the neuromuscular junction. Arrange responses in the correct order to answer the question.