01. Electrophilic aromatic substitution of benzene will not proceed without Lewis acid catalyst. Give the reagent (including catalyst) and the product for the following reactions of benzene. a. nitration b. chlorination c. alkylation d. acylation e. sulfonation 02. Show the Friedel-Crafts acylation reaction of anisole and nitrobenzene with acetic anhydride? Explain the different products formed. 03. What is the basis in the separation of the components of a mixture in chromatography?

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Acylation of Tolueneplease answer 1-3
01. Electrophilic aromatic substitution of benzene will not proceed without Lewis acid catalyst. Give
the reagent (including catalyst) and the product for the following reactions of benzene.
a. nitration
b. chlorination
C. alkylation
d. acylation
e. sulfonation
02. Show the Friedel-Crafts acylation reaction of anisole and nitrobenzene with acetic anhydride?
Explain the different products formed.
03. What is the basis in the separation of the components of a mixture in chromatography?
04. Describe in detail the five basic steps in the thin layer chromatographic (TLC) separation.
05. What is the difference between Rf value and retention time (RT)?
06. The chromatogram represents the separation of the
components of a mixture after development. Calculate the
Rf values of the three components of sample X in the
chrom
gram. If the SP is silica gel C-18, which
the polar
component and the nonpolar component?
c O
Transcribed Image Text:01. Electrophilic aromatic substitution of benzene will not proceed without Lewis acid catalyst. Give the reagent (including catalyst) and the product for the following reactions of benzene. a. nitration b. chlorination C. alkylation d. acylation e. sulfonation 02. Show the Friedel-Crafts acylation reaction of anisole and nitrobenzene with acetic anhydride? Explain the different products formed. 03. What is the basis in the separation of the components of a mixture in chromatography? 04. Describe in detail the five basic steps in the thin layer chromatographic (TLC) separation. 05. What is the difference between Rf value and retention time (RT)? 06. The chromatogram represents the separation of the components of a mixture after development. Calculate the Rf values of the three components of sample X in the chrom gram. If the SP is silica gel C-18, which the polar component and the nonpolar component? c O
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