Hello Colleague! I hope you are having an amazing day! I am very excited that you are leading the clinical trial investigating the co-administration of Levothyroxine. I am happy to help in your understanding of why Levothyroxine is less effective when take in combination with calcium carbonate as opposed to calcium carbonate, which causes minimal interference with Levothyroxine in the body. In order to truly understand what allows Levothyroxine to be effective in treating hypothyroidism we must understand its chemical properties. The three things we must understand are 1.) How levothyroxine can be deprotonated to a sodium salt form, which is more absorbable in the body, 2.) how the Lewis acid Calcium (Ca2+) can interact with and prevent levothyroxine …show more content…
By looking at pKa tables we can determine the most acidic proton is the OH found in the carboxylic acid with a pKa value of around .3. Considering that the pH of the stomach acid ranges from 1.5 to 3.5, we can see that under these conditions the more acidic hydroxyl can be deprotonated. Upon deprotonation, a positive sodium can form an ionic interaction with the now negative Oxygen thereby forming the sodium salt form of Levothyroxine, which is more absorbable by the body. Sodium is used as it among the most common and absorbable ions that exist in the human body and is therefore often used in combination with pharmaceutical drugs. When Ca2+ is acting as a Lewis acid this simply means that it will act as an electron acceptor. We know that upon the deprotonation of the carboxylic hydroxyl Oxygen will have a negative charge. The Calcium could interact to the Oxygen and still hold a +1 positive. This could be problematic in that the Calcium could then interact with the Amine group since the Nitrogen still has a pair of electrons that the Lewis acid Calcium could interact with. Sodium only has an overall +1 charge so it reacts solely with the negative Oxygen allowing to be more easily
Triple Sugar Iron Agar test, there was a gas production seen in the media. The media was yellow slant and yellow butt indicating glucose, lactose and/or sucrose fermentation with acid accumulation in slant and butt. For sulfur reduction, it was negative since it did not turn black in color indicating no sulfur was reduced.
My unknown organism #6 is Morganella morganii, which is a gram-negative bacillus rods commonly found in the environment and also in the intestinal tracts of humans, mammals, and reptiles as a normal flora. (3, 5) This bacterium Morganella morganii, was first discovered in the 1906 by a British bacteriologist named H. de R. Morgan. (2) Despite its wide distribution, it is an uncommon cause of community-acquired infection and is most often encountered inpostoperative and other nosocomial settings. (2, 3) Morganella morganii infections respond well to appropriate antibiotic therapy; however, its
Absorption – “How the drugs enter the circulation process through the body, and how they resist general breakdown by the stomach, liver, and the intestines”. Some of the factors that affect the absorption of drugs in the body is as follows, “acidity of the stomach, Physiochemical properties, Presence of food in the stomach or intestine, and Routes of administration”,
Background: An 83 year old female is taking her levothyroxine medication to help treat her thyroid disorder induced by Hashimoto. She has been taking this medication for thirty years. While always being adherent to taking her medication, she has never really understood what Hashimoto thyroiditis actually is, or why levothyroxine is the best choice of therapy for treating her hypothyroidism caused by the disease. She is also positive for hypertension, GERD, and insomnia.
Unknown lab report# 24 Introduction Microbiology is a study of organisms that surrounds us every day. It requires an educational understanding to identify organisms, and the ability to distinguish different bacteria’s. In applying the learning process of the different bacteria’s, unknown bacteria samples are given to be studied and identified.
The mole is a convenient unit for analyzing chemical reactions. Avogadro’s number is equal to the mole. The mass of a mole of any compound or element is the mass in grams that corresponds to the molecular formula, also known as the atomic mass. In this experiment, you will observe the reaction of iron nails with a solution of copper (II) chloride and determine the number of moles involved in the reaction. You will determine the number of moles of copper produced in the reaction of iron and copper (II) chloride, determine the number of moles of iron used up in the reaction of iron and copper (II) chloride, determine the ratio of moles of iron to moles of copper, and determine the number of atoms and formula units involved in
Studies have shown that untreated celiac disease can cause levothyroxine to not be absorbed like it’s supposed to. Lactose intolerance people who take levothyroxine should be aware that lactose is an inactive ingredient in levothyroxine. Purpose of the study is for people with hypothyroidism that take levothyroxine are aware of the ingredients in the medication and to understand side effects and to have communication with the doctor about what treatment is best for them whether it be traditional capsules or gelatin capsules. The New England Journal of Medicine was used to provide information stomach acid and how it interacts with levothyroxine. In conclusion, levothyroxine has a new formula that comes in a soft gelatin capsule and it’s free of dyes, gluten, lactose, sugar, alcohol, and ingredients that cause allergic reactions. The capsule might be better for certain patients than traditional
An unknown was given to our group from the professor. The unknown was in nutrient broth, the group received unknown number 3. And the task was to identify the unknown and try to make an educated guess, and identify the unknown #3.
How do these electrolytes impact acid-base balance? calcium and magnesium have a synergistic relationship so one enhances the other.
After passing through the esophagus, which absorbs much of the salt ions in the swallowed saltwater, and the gut the luminal fluid is isosmotic with the plasma. The intestines continue to absorb salt (sodium through chloride co-transport proteins and the chloride through the sodium co transport proteins and anion exchange protinis) which is followed by an uptake of water. More chloride is absorbed than sodium which creates an electrogradient in the cell (the cell being more positive and the plasma more negative). The anion exchanger intakes chloride all while excreting HCO3- into the intestinal lumen. The intestinal fluid is highly alkaline, high in HcO3- and high in calcium (from the environment), this allows for CaCo3 to be precipitated in the
Ion trapping is the reason that patients benefit from taking oral salicylates. When ingested, the oral salicylates react with moisture to form salicylic acid and are then broken down by enzymes. The breakdown of salicylic acid into its ionized and unionized components plays an important role in the absorbance of the drug into the body. The highly acidic condition of the gastric secretions of the stomach cause the drug, which is also acidic, to favor it’s unionized and more neutral form. This unionized form is the only form in which the drug can cross the lipid membrane into the plasma of the blood to be absorbed. The neutral environment of the plasma is ideal for the acidic drug to easily diffuse across the membrane. Once it has entered
Given the example that a patient just received an overdose of Ca +2, this will cause the heart rate to go up dramatically. If sodium ions are introduced, this will help with the influx of calcium ions by balancing everything. Certain drugs that act as calcium channel blockers are extremely useful since they reduce electrical conduction within the heart and inhibit the force of muscle cell
The stock solution stability of leuprolide and the IS was evaluated at −20 °C for a month. The bench-top and long-term stability were evaluated to determine the stability of leuprolide in plasma samples under different conditions including bench-top stability, processed sample stability, and freeze-thaw stability. All the stability tests were performed using QC samples at two different concentrations: low (60 pg/mL) and high (8000 pg/mL). The bench-top stability was conducted using QC samples at room temperature for 12 h. The long-term stability was evaluated after the storage of the samples at −80 °C for three months. The processed sample stability was evaluated by analyzing the extracted samples in the sample injector at
The way the reaction shifts is dependent on various factors which influence the equilibrium and Chatelier's principle. These factors include concentration, temperature, volume, and pressure. The Ksp equation for this reaction is Ksp= [Ca+2][C204-2]. By looking at this equation, you can tell that the reaction is very dependent on the concentration of the calcium ions and the acid. For example, if the Ksp value is too large, that means that the concentration of the products is much too high and the equation will shift to the left producing more calcium oxalate which means more kidney stones will be formed. If the Ksp value is too low, than that means that that concentration of the reactants is much too high and the right reaction will be favoured producing more calcium ions and acid. Going back to Chatelier's principle, if the amount of calcium or oxalic acid is increased from equilibrium then the the reaction will shift to the left making more of calcium oxalate. Therefore if someone were to have a diet high in oxalic acid, they would be more likely to form kidneys stones compared to someone who doesn’t eat a lot of foods with oxalic acid. A very basic and easy way to prevent kidney stones from forming is to drink plenty of water