Annotated Biblography 301

Figure 1 shows a 1H NMR spectrum of a solution that was prepared by dissolving 1,3,5-trimethoxybenzene (10.22 mg) in CDCl3 (1.470 g).T What is the concentration in mol dm–3 of CHCl3 present in the CDCl3? (Density of CDCl3 = 1.500 g mL–1.)

DEPT-135 DEPT - 90 DEPT - 45 T 200 CDS-03-521 180 4/5 160 140 - H₂CO T 120 75% + 100 ppm U 80 LL 60 40 20 0

3. 'H-NMR interpretation When dissolved in CDC13, phenacetin shows 6 signals. All of the peaks are sharp, except for the signal f not below. Draw the chemical structure of phenacetin, labeling each hydrogen with an alphabetical letter. Make a larger version of the chart below (half or full page), and complete it with the missing information. Explanation of splitting patter 8 (ppm) Letter # H (integration Splitting pattern value) 7.94 f 1 Broad singlet 7.36 e 6.80 d 3.98 с 2.09 b 1.38 a Extra Credit Question 4. Describe/predict how the 'H-NMR spectrum differs for acetaminophen.

the Infrared spectroscopy experiment  by using(FTIR) to identify the unknow compound from the list : EthanolIsoamyl acetateHexanal1-PropanolAnisaldehydeValerophenoneBenzoic AcidCyclohexanonemethyl iso-butyl ketoneBenzyl alcoholPropionaldehydeBenzaldehydePhenylacetic acid3-methylcyclohexanoneMethanolEthyl acetatePinacolonewhich compound is represented in the picture ?

4. Propose a structure for an organic compound with structural formula CioH13NO2 based on the given IR and H NMR spectra. Explain your answer by interpreting the spectra 7.4 7.2 7.0 6,8 4.0 3.8 1.4 1.2 TMS Impurity 8. 7 5 4 3 2 &H (ppm) 100 90 80 70 60. 50 40 30 20 10 4000 3600 3200 2800 2400 2000 1800 1600 1400 1200 1000 800 650 Wavenumber (cm-) Transmittance (%)

6. Sodium chloride, β-D-fructofuranosyl α-D-glucopyranoside or sodium chloride - β-Dfructofuranosyl α-D-glucopyranoside solutions are used for dehydration of pumpkin.a) Estimate the water activity of 30% β-D-fructofuranosyl α-D-glucopyranoside solution.b) Estimate the water activity of 30% sodium chloride solution.c) Estimate the water activity of solution 20% sodium chloride and 20% β-Dfructofuranosyl α-D-glucopyranoside solution.d) What do you think about the effectivity of these solutions if the water activity of pumpkins are 0.945?

Attempt to explain the main features of the H NMR spectrum of crotonic acid (4), Spec. 4. Deduce the stereochemistry of the carboxylic acid (CO₂H peak not shown). S ... 8 0 SPEC CHCHỊCH CÔ, H 4

6. IR spectroscopy experiment is used to evaluate the success of the reaction. The IR spectra for acetaminophen and phenacetin are shown below. a. Identify which spectrum is for acetaminophen and which is for phenacetin. b. Label the key bond/functional group signals on each spectrum. (eg N-H, C=0, O-H, C=C, C(sp2)-H, C(sp3)-H) OH N H acetaminophen phenacetin 100.0 90 80 70 60 30 40 30 20 10 0.0 40000 3000 2000 1500 1000 400.0 em-1 LOD D 4D00 3000 s0o 2000 1500 1000

Melting point range Recrystallized Phenacetin 95-100 Recrystallized Phenacetin + Reference Phenacetin 110-115 Recrystallized Benzil 92-95 Recrystallized Benzil + Reference Benzil 94-98   Questions: 1.  What does your melting point say about the purity of your phenacetin sample?  Justify your answer using the characteristics of mixed melting point.   2.  What does your melting point say about the purity of your phenacetin sample?  Justify your answer using the characteristics of melting point.   3.  What are two characteristics of a good recrystallization solvent for a given compound?   4. Given a solid sample that contains impurities, how would you determine which solvent to use for a recrystallization?  Describe how you would do this in the laboratory.   5. Clearly explain the difference between a recrystallization and a precipitation.

WILL HEXANE DISSOLVE  fenethylline IN GC-MS?

Assign the following infrared spectra (Spectrum I and Spectrum II) to a solution of nonanal and acetic acid. Give reasons for your answers. H3C. H3C. TH. nonanal acetic acid Spectrum 1 100 2000 1000 4000 3000 BAVENUERIl 1126 62 1068 57 375 50 866 79 775 84 723 57 676 1 3436 66 2956 10 670 01 S28 81 1467 25 1411 44 1390 1979 70 2926 13 44 41 2872 2856 36 1305 2716 1251 72 1728 10 1146 47

When 1-bromobutane is treated with sodium acetate (CH3CO,Na), the major product for the reaction is an ester (CH;CO2CH2CH2CH2CH3). Explain how mass spectrometry and IR spectroscopy could be used to prove that the reaction has occurred and you no longer have the starting material.

A student was trying to determine the identity of an unknown compound.  The melting point of the compound was 117-118oC. The student narrowed the possible compound down to the following:   Compound Melting Point Range acetanilide 113-115oC fluorene 114-116oC mandelic acid 120-122oC A second student, doing the same experiment as above, found that their melting point was 100-108oC.  What is wrong with the student’s melting point? Propose two reasons why the melting point could be incorrect. View keyboard shortcuts

-) Explain the partial solubility of cyclohexanone in wakr.

1. An aliphatic ketone absorbs at 1,715 cm-1. What is the frequency of this vibration in hertz, which is cycles per second or just per second, reciprocal seconds? 2. What is the energy equivalent of this stretching vibration in kcal/mole? 3. Why does 3,4-diethyl-3-hexene not have a carbon to carbon double bond stretching absorption band? 4. Why does a carbon to oxygen double bond absorption band have a greater intensity than a carbon to carbon double bond absorption band? 5. Using only IR, explain in detail how one could most easily differentiate between oct-1-ene and oct-1-yne if all carbon to carbon bonds are ignored. 6. Using only IR, explain in detail how one could most easily differentiate between butan-1-ol and butanoic acid.

Find information on: 1. DDT 2. EDTA 3. orotic acid 4. сarboplatin 2. Propose the approximate shift/splitting pattern/etc. for each type of hydrogen that would be seen in an 'H-NMR spectrum Identify the # of each type of each carbon (i.e. how many peaks in the 13C spectra) 3. Identify infrared (IR) active bonds within each molecule 4.

The partial ¹H NMR spectrum for ester A is as below. 10 (i) (ii) (iii) Hc. H₂ 9 Ha 8 OCH 3 7 6 5 Give the approximate chemical shifts for protons H₂, H₂ and Hc. Explain the difference in chemical shift for Ha and Hc. Name the splitting pattern for Ha.

When 1-bromobutane is treated with sodium acetate(CH3CO2Na), the major product for the reaction is an ester (CH3CO2CH2CH2CH2CH3). Explain how mass spectrometry and IR spectroscopy could be used to prove that the reaction has occurred and you no longer have the starting material.

Account for the formation of the base peaks in these mass spectra. Q.) Isobutylmethylamine, m/z 44

Pease indicate the compound that best fits in the blank of the separation scheme below. OH H2N Benzoic Acid Biphenyl Benzocaine Phenol benzocaine phenol biphenyl benzoic acid dissolve in ether; extract with aqueous 19)_ ether aq 20) CO,(g) H2O HIDDEN COMPOUND 1 HIDDEN COMPC HIDDEN COMPOUND 3 trace 21) |6.0 М НСI aq 22) NaCl H20 Which of the following is the best choice for blank 22 in the given separation scheme? phenol O benzocaine O biphenyl water O benzoic acid

Analysis of 1 5-bis(4’-methoxyphenyl)-1 4-pentadien-3-one by NMR. Please label the chemical shift (ppm), integration, splitting (single, doublet, triplet), and fragments (C-C). Is the C double bond C cis or trans?

2. For the following synthesis of sertraline, what are the advantages and disadvantages from a green chemistry perspective? 유 NCH,+H NCH+Ho-C-CH CH-O CH V MMA/TICI. THE NCH, non-isolation VI 1. H./Pd/THF 2. HCI NCH, HCI VII D(-) mandelic acid EtOH CI XXIII EtOAc/HCI NCH, + HCI VIII

Account for the presence of peaks at mlz 135 and 107 in the mass spectrum of 4-me- thoxybenzoic acid (p-anisic acid). H,CO- -COH 4-Methoxybenzoic acid

BocHN, Surya was leaving the lab in a hurry and forgot to note which unknown he added. From the reaction scheme below and the GC-MS. Help Surya figure out whether he added the chlorinated compound, or the brominated compound to his reaction. Label the base peak and molecular ion peak. CH, NH₂ Br or Cl ♦ Relative intensity 100- 80- 60- 40- 8 Acetonitrile Water (9:1) 6h 100 BocHN, CH₂ 150 m/z 200 TFA DCM (19) 1h 250 H₂N.

TLC, a powerful analytical tool, can be used to monitor the progress of reactions. The synthesis of ethyl-3-coumarincarboxylate can be monitored by TLC by displaying the starting aldehyde 1, and coumarin product 2, which have very distinct Rf values (Hint: Think about the polarity of compounds 1 and 2 in terms of their abilities to H-bonds to silica gel). What can be determine about the progress of the reaction from analysis of the TLC shown below?

8. One stereoregular form of polystyrene (A) has a 'H NMR spectrum containing a triplet centered at about 1.4 ppm and a quintet at about 1.9 ppm. Another stereoregular form (B) has an octet at about 1.6 ppm and a quintet at about 2.3 ppm. (Both spectra also exhibit phenyl proton resonances further downfield.) Interpret the spectra and determine which corresponds to isotactic and which to syndiotactic. (Syndiotactic polystyrene was first reported by N. Ishihara and co-workers in a 1986 paper. You may wish to locate the paper and check your answer.)

how to analyse alkaloids using Acid dye colorimetry method and HPLC method? Discuss atleast 5 sentences each