Microbiology: An Evolving Science (Fourth Edition)
Microbiology: An Evolving Science (Fourth Edition)
4th Edition
ISBN: 9780393615098
Author: John W. Foster, Joan L. Slonczewski
Publisher: W. W. Norton & Company
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Chapter 24.1, Problem 1TQ
Summary Introduction

To review:

The reciprocation of specific immune response to amino acid stretches of 3D antigen.

Introduction:

The immune system of a host is comprised of various biological structures and processes that help in protection against diseases. It consists of major parts like bone marrow, thymus, lymphatic system, complement system, and spleen. There are two types of immunities that are provided by the immune system.

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Name the two types of antibody light chains.
alpha:beta TCRs are membrane-bound proteins comprised of two polypeptides linked by a disulfide bond. Both polypeptide components of the alpha:beta TCR are members of the immunoglobulin superfamily, and each of their domains share structural similarity with regions of antibody proteins. However, due to the different functions of TCRs versus antibodies, the overall domain organization of the TCR is not the same as for an antibody. In the figure below, describe three features that are incorrect illustrations of the alpha:beta TCR.
Which cleavage pattern (indicated by the red triangles in figure below) yields a fragment that has the same antigen-binding avidity as the intact antibody, but is unable to activate complement after binding to a pathogen?
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