In relation to immunotechnology, answer the following:
A- Answer the following in relation to Hybridoma technology:
→ What is the cancer cell line name used in hybridoma technology?
→ Give an example of murine Monocolonal Antibody produced by hybridoma technology?
B- Give ONE main difference between: Murine MABs and fully human MABs?
and explain the reason behind developing different forms of Monoclonal antibodies (chimeric MABs, humanized MABs, and fully human MABs)
C- You are in an internship in one major Hospital, You were in rotation with a clinical pharmacist in oncology section and you came over a breast cancer patient. The personal doctor was making a quick visit to the patient to make sure the patient is following the therapeutic protocol and the treatment is running smoothly. The doctor wrote in the prescription sheet “Trastuzumab” to be dispensed by the In Patient Pharmacy, when the clinical pharmacist saw this he advised the doctor politely to use the trade name of the medication as this is more appropriate for dispensing such biological preparation. Answer the following:
- What is the type of monocloncal antibody of “Trastuzumab”?
- What is the trade name of “Trastuzumab”?
- Give one example of a biosimilar for “Trastuzumab”.
- Which action is appropriate in prescribing “Trastuzumab”: the doctor or the clinical pharmacist. Explain why?
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