Organic And Biological Chemistry
7th Edition
ISBN:9781305081079
Author:STOKER, H. Stephen (howard Stephen)
Publisher:STOKER, H. Stephen (howard Stephen)
Chapter9: Proteins
Section: Chapter Questions
Problem 9.57EP
Related questions
Question
A peptide has the sequence
Glu–His–Trp–Ser–Gly–Leu–Arg–Pro–Gly
The p?a values for the peptide’s side chains, terminal amino groups, and carboxyl groups are provided in the table.
Amino acid | Amino pKa | Carboxyl pKa | Side‑chain pKa |
---|---|---|---|
glutamate | 9.609.60 | 2.342.34 | 4.254.25 |
histidine | 9.179.17 | 1.821.82 | 6.006.00 |
tryptophan | 9.399.39 | 2.382.38 | |
serine | 9.159.15 | 2.212.21 | |
glycine | 9.609.60 | 2.342.34 | |
leucine | 9.609.60 | 2.362.36 | |
arginine | 9.049.04 | 2.172.17 | 12.4812.48 |
proline | 10.9610.96 | 1.991.99 |
Calculate the net charge of the molecule at pH 11 and estimate the isoelectric point (pI)(pI) for this peptide.
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Recommended textbooks for you
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning
World of Chemistry, 3rd edition
Chemistry
ISBN:
9781133109655
Author:
Steven S. Zumdahl, Susan L. Zumdahl, Donald J. DeCoste
Publisher:
Brooks / Cole / Cengage Learning
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning
World of Chemistry, 3rd edition
Chemistry
ISBN:
9781133109655
Author:
Steven S. Zumdahl, Susan L. Zumdahl, Donald J. DeCoste
Publisher:
Brooks / Cole / Cengage Learning
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning
Introductory Chemistry: A Foundation
Chemistry
ISBN:
9781337399425
Author:
Steven S. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
World of Chemistry
Chemistry
ISBN:
9780618562763
Author:
Steven S. Zumdahl
Publisher:
Houghton Mifflin College Div