Each ionizable group of an amino acid can exist in one of two states, charged or neutral. The electric charge on the functional group is determined by the relationship between its pKą and the pH of the solution. This relationship is described by the Henderson-Hasselbalch equation. Histidine has three ionizable functional groups. Complete the equilibrium equations by assigning the proper pKą for each ionization and the net charge on the histidine molecule in each ionization state. H || H,N*-C-C-OH H|| H,N*-C-C-o- H|| H,N*-C-C-o- H|| H,N-C-C-o- CH, CH, CH, CH, HN HN N -NH -NH -NH -NH Answer Bank pKa = 6.0 -1 pK = 9.17 +2 -2 +1 pk = 7.59 pk = 1.8 %3D 1 1
Each ionizable group of an amino acid can exist in one of two states, charged or neutral. The electric charge on the functional group is determined by the relationship between its pKą and the pH of the solution. This relationship is described by the Henderson-Hasselbalch equation. Histidine has three ionizable functional groups. Complete the equilibrium equations by assigning the proper pKą for each ionization and the net charge on the histidine molecule in each ionization state. H || H,N*-C-C-OH H|| H,N*-C-C-o- H|| H,N*-C-C-o- H|| H,N-C-C-o- CH, CH, CH, CH, HN HN N -NH -NH -NH -NH Answer Bank pKa = 6.0 -1 pK = 9.17 +2 -2 +1 pk = 7.59 pk = 1.8 %3D 1 1
Chemistry: Principles and Reactions
8th Edition
ISBN:9781305079373
Author:William L. Masterton, Cecile N. Hurley
Publisher:William L. Masterton, Cecile N. Hurley
Chapter23: Organic Polymers, Natural And Synthetic
Section: Chapter Questions
Problem 31QAP: On complete hydrolysis, a polypeptide gives two alanine, one leucine, one methionine, one...
Related questions
Question
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Recommended textbooks for you
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,
Introduction to General, Organic and Biochemistry
Chemistry
ISBN:
9781285869759
Author:
Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:
Cengage Learning
World of Chemistry
Chemistry
ISBN:
9780618562763
Author:
Steven S. Zumdahl
Publisher:
Houghton Mifflin College Div
World of Chemistry, 3rd edition
Chemistry
ISBN:
9781133109655
Author:
Steven S. Zumdahl, Susan L. Zumdahl, Donald J. DeCoste
Publisher:
Brooks / Cole / Cengage Learning