4. Phenylketunoria (PKU) is an inborn error of metabolism of the amino acid phenylalanine. The following pedigree is of an affected family. I II III 1 2 3 4 5 a. What is the mode of inheritance of PKU? b. Which persons are known to be heterozygous for PKU? Identify from I, II, and III generations. c. What is the probability that III-2 9 is heterozygous?
Q: 4. An albino corn snake is crossed with a normal-coloredcorn snake. The offspring are all…
A: The basic physical and functional unit of inheritance is termed as a gene. It is made up of DNA.…
Q: 9. Please determine whether the allele responsible for the trait is dominant or recessive. (A) (B)…
A: Pedigree analysis gives an idea how the disease is transferred from parents generation to next…
Q: 4. Consider the characteristics and pedigree of a couple: Woman: has normal vision but mother is…
A:
Q: Your uncle (your mother's brother) has a rare genetic disease that is inherited in an autosomal…
A: The alleles are the alternative forms of a gene that are located on the same locus of a homologous…
Q: 6. A person is simultaneously heterozygous for two autosomal genetic traits. One is a recessive…
A: (a) Figure of the metaphase of mitosis is as follows:
Q: 2. Assuming complete penetrance, which type of inheritance pattern is consistent with the pedigree…
A: Pedigree is a diagrammatic representation of either phenotypes or genotypes of a particular organism…
Q: 7) Osteogenesis imperfecta (OI), also known as brittle bone disease, lead to fragile bones that tend…
A: Autosomal recessive inheritance is a genetic trait that is passed on to the offspring from parents.
Q: 1. Black fur (B) in guinea pigs is dominant over white fur (b). A homozygous black and a…
A: A phenotype is a trait or a characteristic that can be observed in an organism. It results from the…
Q: 6 What is the most likely mode of inheritance in the pedigree depicted to the right? a. Fully…
A: Genetics is the study of inheritance from parents to offspring to understand how genetic information…
Q: 1. Fur color of rats is determined by the pathway below. The mating between brown rats of identical…
A: Genotype can be defined as the collection of all the genes present in the body. It is consists of…
Q: A strain of Neurospora with genotype A B is crossed with a strain with the genotype a b. Half the…
A: In Neurospora , there are two types of genes : A and B . Genotype of :- Parent I :- A B Parent II…
Q: If you were at risk of a fatal disease such as Huntington’s disease and only the 95% accurate…
A: To describe Whether or not to take the genetic test, if you were at risk of a fatal disease such…
Q: 3. Determine if the pedigree below can be for a trait that is autosomal dominant. a. Write the…
A:
Q: 1. A disease is known to be inherited through an ADHL mode of inheritance. For a pairing of two…
A: ADHL: Autosomal dominant hearing loss. Autosomal dominant disease: single copy of a mutant gene has…
Q: 4. Instead of one big square it is much easier to make two small Punnett squares, one for each gene.…
A: Pls refer below for solution :
Q: 4.Eyelash length is an inherited trait. In the human population, there is an eyelash length gene.…
A: Alleles are already form of a gene that that are located on the same locus of a homologous…
Q: 7. Below is a pedigree for a family in which some members have achondroplastic dwarfism, This trais…
A: *Autosomal dominant inheritance is a genetic condition taht can be passed from parent to child that…
Q: 1. Miguel wants to know if his musical talent comes from his great-great grandfather Hector. When…
A: Hello. Since you have posted multiple questions and not specified which question needs to be solved,…
Q: 4) A testcross is used to determine which of the following? a) The phenotype of an individual with…
A: In diploid organisms, the phenotype is expressed when one allele (alternative form of a gene) is…
Q: 16) If this is an autosomal recessive disorder, how many individuals found in the pedigree have…
A: The autosomal recessive disorder occurs if the disease gene is present on nonsex chromosomes,…
Q: 6) For the pedigree shown below, answer the following questions. I II II I a) What type of…
A: Pedigree analysis helps us identifying the mode of inheritance of a particular disease by observing…
Q: 2. Fill out the blanks of the pedigree (AA, Aa, or aa). a) How many children did the original couple…
A: Note - The first question is not complete. So solving question - 2 for you. Question-2 Given: A…
Q: In humans, red-green color blindness is a. equally common in both sexes b. caused by a recessive…
A: Colour blindness is an inherited disorder which is a sex linked disorder. Male are more affected…
Q: 8. This family pedigree follows a family afflicted by a trait determined by the R gene IdA 2 9 10 11…
A: A gene is a unit of genetic material and alleles are the alternative form of genes present at the…
Q: 1. An albino man whose parents are both normal marries a woman ome of whose parents is normal and…
A: Albinism is a autosomal recessive transmission pattern disease. Suppose the genotype of Albino is aa…
Q: 1. (a) You are a genetic counsellor at Penang General Hospital. A couple comes to you worried about…
A: Sickle cell anemia is a genetic disorder in which the shape of red blood cell changes into crescent…
Q: 8 Huntington's Disease is a rare neurodegenerative disorder caused by a defective gene. A pedigree…
A: Answer. A pedigree is a family tree or chart made of symbols and lines that represents a persons…
Q: 4)If an individual is bald, so you can't tell whether or not they have a widow's peak, but neither…
A: A widow's peak is defined as a V-shaped point present in the hairline in the center or middle of the…
Q: 7. Assume that one of Squidward's sons, who is heterozygous for the light blue body color, married a…
A: The Punnet square is the square diagram that is used to predict the genotypes of particular cross or…
Q: 5. For each of the following pedigrees, indicate whether the pattern of inheritance is recessive or…
A: Given, are two pedigree charts. Pedigree charts display a family tree which shows the members of the…
Q: 5. A man with a specific unusual genetic trait marries an unaffected woman and they have four…
A: X-linked disorders are those diseases in which the mutated genes are present on the X chromosomes…
Q: 1.What are the phenotypes of the parents of the corn dihybrid cross described above? 2. What are…
A: The phenotype represents the morphological expression of the genes.
Q: 22. Refer to the pedigree to the right. If individual III-2 marries a person with the same genotype…
A: The given pedigree shows the inheritance pattern of haemophilia in a family. The oval represent the…
Q: . A man with O blood type marries a woman with AB blood type. What are the expected genotypic and…
A: The blood group of human biengs is decided by the enzymes present on the surface of RBC membrane .
Q: 4. In this pedigree of another family with hemophilia A. If the woman Il-2 has a son, what is the…
A: Answer: Hemophilia is the X-linked recessive disorder which is transferred from parents to…
Q: 3) In the snail Capaea nemoralis, an autosomal allele causing a banded shell (B³) is recessive to…
A: The banding and colour are linked genes on the same chromosome. But there are no crossing overs.
Q: 3. This pedigree is for the autosomal dominant trait achondroplasia (use letter A as allele/s), a…
A: (According to Bartleby guidelines, only the first three have been answered. Kindly post the…
Q: 1. In humans, normal pigmentation is due to a dominant gene A. Albinism is due to the recessive…
A: Albinism is an autosomal recessive disease. The presence of homozygous recessive genotype encodes…
Q: 1. In the pedigree below, Use "A" for the allele associated with the dominant phenotype, and…
A: A pedigree chart shows the inheritance pattern of a particular trait. Each row contains the…
Q: 9. Explain, giving reasons, whether the following pedigrees are compatible with autosomal dominant,…
A: Answer : autosomal dominant The disease is present in the parents and there is no skip in the…
Q: 4. In dogs, the tendency to bark while traliling is due to a dominant gene while silent trailing is…
A: In dogs, the tendency to bark while trailing is dominant over silent trailing. Let the gene…
Q: 1. A man with a rare genetic trait marries an unaffected woman and they have four children (first…
A: Father is affected and mother is unaffected. Mother is neither a carrier nor is affected by the rare…
Q: 2. Indicate possible patterns of inheritance for the RARE traits shown in each of the pedigrees…
A: This particular pedigree shows following traits: 1. The affected trait appeared in generations in…
Q: 1. Windows peak (S) is dominant over straight hairline (s). Given that the mother has heterozygous…
A: As per our honor code, I am allowed to answer only three subparts. So, I am answering three parts.…
Q: 2. In humans, thalassemia shows incomplete dominance; heterozygotes exhibit a mild form of the…
A: Let major thallesemia be denoted as tt and minor thallesemia be denoted as Tt. The couple has minor…
Q: 1. In mice, black fur (B) is dominant over brown fur (b). Breeding a brown mouse and black mouse…
A: When a dominant genotypes is crossed with the recessive phenotype F1 results in all dominant…
Q: In a pedigree analysis a family shows a possible autosomal recessive inheritance, however karyotype…
A: Different tools are employed to study various fields of genetics. A knowledge of parentage, the…
Step by step
Solved in 3 steps
- A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What is the chance that this couple will have a child with two copies of the dominant mutant gene? What is the chance that the child will have normal height?A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. Should the parents be concerned about the heterozygous condition as well as the homozygous mutant condition?1. The pedigree chart in Figure 5.29 shows the inheritance of haemopiu family. Study the pattern of inheritance in the pedigree chart, and then answer the questions that follow. о 5 6. 3 8 9 10 11 Key Unaffected male Haemophiliac male О Unaffected female Fig. 5.29 Pedigree chart of a family affected by haemophilia a) What is the genotype and phenotype of individuals 2 and 4? b) (i) How many of the unaffected family members are definitely carriers of the recessive allele? (ii) How are you able to tell which of the family members are carriers? (4) (1) (3) c) (i) If Individual 11 marries a carrier female, what percentage of their sons is likely to be haemophiliacs? (1) (ii) Use a genetic diagram to show how you worked out your answer in i, (6) 2. Why is haemophilia never passed from father to son, even though it is most common in males? (4) 3. Can a mother pass on a sex-linked gene to her daughter? (1) 4. Sipho has red-green colour blindness. One of his grandfathers was also. colour…
- the offspring ès) can often be autosomal I 1.1 III ad amalg od no IV 9 OTO 5 0000 anivellor and goje If individual 2 were to marry a woman with no family history of the disease, which of the following would most likely be true of their children? a. All of the children would have the disease. b. None of the children would have the disease. c. Only the sons would have the disease. d. All of the sons would be carriers of the disease. e. None of the daughters would be carriers of the disease.4. In this pedigree of another family with hemophilia A. If the woman Il-2 has a son, what is the chance that he is affected? II B. If the woman Il-2 has a daughter, what is the chance 1 2 3 4 III that she is affected? -1 C. If the woman Il-2 has 2 sons, what is the chance that neither will be affected? D. What are the chances that the child of II-4 and Il-5 will be affected?11. Below is a pedigree chart of an autosomal recessive disorder. Answer the following questions using the correct genetic terminology (do not just write letters like “Ee”). A. What is the genotype of individual 1 in generation II? B: What is the genotype of individual 2 in generation I?C: Is it true that individuals 6, 7, 8, 9, and 10 in generation III all have the same genotype? Why or why not?
- BB AB AB A. None B.3 с.1 D.2 ВВ OE. The father AB In the pedigree presented above, an autosomal dominant disease which causes significant visual loss and eventual blindness, is segregating in the family. The disease gene causing this sight loss looks as if it may be linked to a marker locus. The alleles of this marker locus that are present in this family are allele A and allele B. Are there any recombinant individuals in this pedigree? AB ВВ AB ВВ AB ВВ AB AB ВВPATERNITY TESTING Family Inheritance of STR AIleles (D13S317) 110 11 14 Father 12 14 Child al 14 Child a2 11 12 Child a3 12 Mocher A). What is the meaning of the numbers above the peaks for the father? B). How many Child/children belong to both parents? C). Define STR D). Define D13S317tion 8: below is the pedigree of inheritance of phenylketonuria (PKU). We will designate the letter Caven for the dominant allele and "p" for the recessive allele. 4 The pedigree shows that the pattern of inheritance for the allele for phenylk ylketonuria is: I. II. 1 III. IV. Autosomal dominant Autosomal recessive X-linked dominant X-linked recessive b. The parents in generation I have how many children: I. 3 Boys II. 3 Girls III. IV. 3 Boys and 1 Girl 3 Girls and 1 Boy c. What is the genotype of individual 1 in generation III: I. PP II. pp III. Pp " O 1 III. 50% E III 1 ▬ 2 2 IV. 25% 1 3 IV. Can be PP or Pp ii. Suppose that a man having type AB blood marries a woman having type O blood. What is the probability that their child will have type A blood? I. 100% II. 75% 2 4 3
- 14. ii) If Individuals #6 and #7 have another daughter what are the chances that she will be affected. 1 II IV a) The pedigree above shows the passing on of colorblindness. What sex is MOST likely to be carriers of colorblindness? b) Why does individual IV-7 (a female) have colorblindness? c) Why do all the daughters in generation II carry the colorblind gene? d) List two h generation colorblind males. 15. Explain sex linked inheritance with examples. 16. Explain what happens during these following sicknesses and why it happens? i) Sickle cell anemia i Hemophilia 17. What do you understand by the term "Multiple Alleles"? Define the followings: Trait true breeding cross P generation F1 generation monohybrid cross F2 generation dominant recessive law of segregation genotype phenotype homozygous heterozygous test cross dihybrid cross law of independent assortment pedigree autosomal recessive Punnett square autosomal inheritance autosomal dominant1. What is the pattern of inheritance of 5-Alpha Reductase 2 Deficiency? answer choices: X-linked recessive X-linked dominant autosomal recessive autosomal dominant maternal/mitochondrial Y-linked 2. What is the likely genotype of individual V-8? a = recessive allele A = dominant allele What is the likely genotype of individual V-8? a = recessive allele A = dominant allele answer choices: XaY XAY aa Aa AA 3. Imagine that individual V-8 marries a female cousin who is a carrier of the 5αRD mutation. What is the probability that they will have a child who has the disorder? Enter your answer as a fractiona. b. 1 2 3 Note: Cystic fibrosis in this family is caused by a recessive allele that is found on chromosome 7. A genetic counsellor collected pedigree information regarding the incidence of cyctic fibrosis within this family. The row that indicates the genotypes of individuals 1-1, 1-2, and II-2 is Select one: C. Pedigree of a Family with Cystic Fibrosis PTO 1 2 d. I II I-1 XAY I-1 AA I-1 XAY I-1 Aa 1-2 хаха 1-2 aa 1-2 ΧΑΧΑ 1-2 Aa II-2 XAY 11-2 Aa II-2 хау II-2 aa O