9. Explain, giving reasons, whether the following pedigrees are compatible with autosomal dominant, autosomal recessive or X-linked dominant and X-linked recessive inheritance. (Note that a pedigree may be compatible with more than one type of inheritance.) 12 12 1:1 1:2 다 I12 I13 IIS I12 13 Il:1 I1:2 I1:3 Il:4 III:1 III:2 III:3 III:4 a. b. C.
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- 1. What is the pattern of inheritance of 5-Alpha Reductase 2 Deficiency? answer choices: X-linked recessive X-linked dominant autosomal recessive autosomal dominant maternal/mitochondrial Y-linked 2. What is the likely genotype of individual V-8? a = recessive allele A = dominant allele What is the likely genotype of individual V-8? a = recessive allele A = dominant allele answer choices: XaY XAY aa Aa AA 3. Imagine that individual V-8 marries a female cousin who is a carrier of the 5αRD mutation. What is the probability that they will have a child who has the disorder? Enter your answer as a fraction6. Identify the mode of inheritance for the following pedigree. Provide the genotypes of indicated individuals. ? Genotypes: Il-1 IV-1 V-6 Il-2 IV-2 V-12 Il-3 IV-3 V- 14 III-1 IV-4 V-16 III-13 V- 1 V-19II. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked dominant and b) X-linked recessive in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xª, depending on mode of transmission of the disease respectively. *Unaffected/No carrier-Normal Unaffected X chromosome = X I || III 1 1 2 a) X-linked recessive 9 III 6 genotype (circle one): XX * 1 2 3 11x12 4 ΧΑΧΑ 2 5 xaxa *4 6 7 8 b) X-linked dominant 11 x 12 오 XAX хах
- 15 1 point What is the most likely mode of inheritance of the disease depicted in the following pedigree? ||| IV 1 autosomal dominant autosomal recessive 2 N 1 2 2 3 3 4 3 4 5 --DWhat is the most likely mode of inheritance for this trait? I 1 2 1 2 3 4 6 7 OLO 2 3 4 5 6 7 8 9 10 4 5 6 II E III IV 1 □□ 1 2 3 X-linked dominant X-linked recessive Y-linked autosomal recessive autosomal dominant 510. Examine the pedigree from a family with a genetic disease and answer the questions below: 1:1 1:2 I1:1 II:2 I1:3 Il:4 II:5 I1:6 II:1 III:2 II:3 I:4 III:5 II:6 a) Does this pedigree indicate autosomal dominant, recessive or sex- linked type of inheritance? Give reasons for your choice. b) Assuming that B and b are the normal and mutant alleles respectively, what would be the genotypes of the individuals: II.1, II.2 and III.3 ? c) Individual II.3 requested genetic counselling. What is the probability that her child would be affected. Explain why.
- re ||| E 6. Label the genotypes for this pedigree of an X-linked recessive disorder (red- green colorblindness). (a) 2 2 3 1 3 a. How do you know? b. Label the genotypes. 4 O To 2 4 5 5 6 6 7. Is the following pedigree autosomal recessive, autosomal dominant or X-linked recessive? 2 8 O T 582. Hemophilia is an X linked recessive trait. There is a woman who is a carrier for hemophilia and marries a man with hemophilia. a) Complete the Punnett Square (it is a google drawing so you will have to double click it to go to the drawing and type in and around the square. Hold the CONTROL (or Command) button and press the PERIOD button to write a superscript/exponent.) b) What are the possible genotypes of the children? c) Could any of their children have hemophilia? If so, would the child be male or female? Explain your reasoning.1) Symptoms of 4 disorders are listed. Using the lists given, fill in the correct letter for the condition name and inheritance type. Letters may be used more than once. Symptoms Condition Inheritance Туре Loss of muscle control and decline in mental ability Shades of red and green are hard to distinguish Lack of skin pigmentation Cannot produce one of the necessary blood clotting factors Conditions: Inheritance Type: A: Albinism E: X-linked dominant B: Huntington Disease F: X-linked recessive G: Y-linked C: Hemophilia H: Autosomal dominant I: Autosomal recessive D: CVD
- 8. This family pedigree follows a family afflicted by a trait determined by the R gene IdA 2 9 10 11 12 13 14 15 16 17 18 19 e. What is the genotype of individual 1: f. What is the genotype of individual 6: g. What is the genotype of individual 2: h. What is the genotype of individual 13: i. Is this trait autosomal dominant, recessive, or X-linked recessive? Why? |1. Given the following pedigree below, use Punnett squares for each of the following possibilities: a) X- linked recessive and b) X-linked dominant in order to determine what is the mode of transmission of this trait. Disease allele = XA or Xa, depending on mode of transmission of the disease respectively. *Unaffected/No carrier-Normal Unaffected X chromosome = X I 11 * 1 2 1 2 3 a) X-linked recessive 11x12 III 2 genotype (circle one): XY 4 XAXA 2 3 5 Xaya *4 6 7 8 b) X-linked dominant 11x12 XAY Xay1 II 1 4 6. II 1 2 4 5 6. 8. IV The above image shows a pedigree for a monogenic inherited disease. Although this trait is only observed in males in this family, the pattern of inheritance of this disease is autosomal recessive. Use the pedigree to explain why the inheritance of this disease cannot be autosomal dominant. If this trait is X-linked recessive, what would be the genotypes of the people in Row I? 2. 2. 3. 2. 3.