3. SRD5A2 What is the role of this gene in development of external genitalia? Does this gene act in a simple Mendelian matter to determine whether external genitalia are male or female? (Note: XY people with a deficiency in this gene have a phenotype similar to the one shown by Caster Semenya in the video. If she has been tested for this condition, the results have not been made public.)
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Genetics Question 3
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- 8. Identify the following. Gene found on Y chromosome but not X chromosomes Protein coded for by SRY gene Function of testis determining factor (TDF) Organ that secretes testosterone and Mullerian inhibiting factor (MIF) Hormone that promotes development of external genitalia along male line Protein that transforms Wolffian ducts into male reproductive tract organs Organ that develops in the absence of TDF SRY gene sex-determining region Y protein initiating male sex determination Testosterone4. In fruit flies, opaque wing color is due to an X-linked dominant version of a gene. A female with opaque wings mates with a male with opaque wings. Based on this information, which of the following statements is accurate and can be stated with 100% confidence iregarding their offspring? A) female offspring have a 50% chance of having opaque wings B) males are guaranteed to have a 100% chance of having opaque wings C) female offspring cannot have opaque wings D) males are guaranteed to have a 50% chance of having opaque wings E) none of the above statements are completely accurate due to inadequate information provided6. A man with X-linked colorblindness marries a woman with no history of ibba colorblindness in her family. The daughter of this couple marries a normal man noitenmot and ended up hone daughter, and their daughter also marries a normal man. This mont blast couple has already had a child with color blindness. do sri ni novig A) What is the chance that next child will be color blind? B) What is the chance that this last couple will have an affected daughter? (d #50x²50 (
- Mutations Can Uncouple chromosomal Sex from Phenotypic Sex Discuss whether the following individuals (1) have male or female gonads, (2) are phenotypically male or female (discuss Wolffian/Mllerian ducts and external genitalia), and (3) are sterile or fertile. a. XY, homozygous for a recessive mutation in the testosterone biosynthetic pathway, producing no testosterone b. XX, heterozygous for a dominant mutation in the testosterone biosynthetic pathway, which causes continuous production of testosterone c. XY, heterozygous for a recessive mutation in the MIH gene d. XY, homozygous fora recessive mutation in the SRY gene that abolishes function. Researchers discovered recently that the sole functionof the SRY protein is to activate an autosomal genecalled Sox9 in the presumptive gonad (before it has“decided” to become a testis or an ovary).a. What would be the sex of an XY individual homozygous for nonfunctional mutant alleles of Sox9?Explain.Question 15: Consider the consequence if one of the mutations you tested for complementation was a dominant mutation. You should see that complementation tests could not be used to provide information about dominant mutations. a) If a mutation were dominant how would your interpretation of the phenotype of the diploid be altered? No change would occur v b) How would you test whether any of these trp mutations were dominant? There is no way to test fc V
- 1. If an A a Bb C cdd male mates with an A a Bb CC DD female. (a) What is the minimum number of ridge-producing genes possible for a child of this couple? (Show your work. Hint: solve gene by gene) (b) what would be the TRC for this child if it is male? (Show your work: give the formula, place appropriate number in formula and then solve equation). (c) what would be the TRC for this child if it is female? (Show your work: give the formula, place appropriate number in formula and then solve equation).y 301 Amelogenesis imperfecta is X-linked dominant. Affected XY individuals have extremely thin enamel on the teeth while XX carriers have grooved teeth from uneven deposition of enamel. If an unaffected XY individual were to produce children with a XX carrier partner, a. what would be the expected chance of a XY child being affected with the disease? b. what would be the expected chance of a XY child being affected with the disease?Chorionic villus sampling (CVS) is used to test for genetic disorders in the fetus and can be performed early in gestation (8-10 wks). The recommended method of CVS is to sert a probe with a needle on the end through the cervix and remove a small sample of e chorionic villi to be analyzed. Which description is a correct description of chorionic villi? Select one: They are found in the digestive tract of the fetus. They are developed from the endometrium. They contain cells whose nuclei differ genetically from cells of the fetus. They form part of the placenta.
- A mutation occurs in the bicoid gene in a female fly. What will result if her eggs are fertilized? 1.Her embryos will be normal if they are fertilized by a male fly that contributed a wild type allele for bicoid 2.Her embryos will be normal if the male that fertilizes her eggs also has that same bicoid mutation 3.All of her embryos will be disrupted irrespective of the genotype of the father 4.Her embryos will develop normally but the adults will be sterileDiscuss and compare the source (mechanism) and types of increased mutations in older mother oocytes versus older father sperm (ch 4 and ch 7.) (Diagrams may be helpful if needed to convey your thoughts.Certain forms of human color blindness are inherited as X-linkedrecessive traits. Hemizygous males are color-blind, but heterozygous females are not. However, heterozygous females sometimeshave partial color blindness.A. Discuss why heterozygous females may have partial color blindness.B. Doctors identified an unusual case in which a heterozygousfemale was color-blind in her right eye but had normal colorvision in her left eye. Explain how this might have occurred.