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- Hemophilia A is transmitted by an X-linked recessive gene.With an affected father, what is the probability that a childwill have the disease? With an affected father and a carriermother, what is the probability?6. A man with X-linked colorblindness marries a woman with no history of ibba colorblindness in her family. The daughter of this couple marries a normal man noitenmot and ended up hone daughter, and their daughter also marries a normal man. This mont blast couple has already had a child with color blindness. do sri ni novig A) What is the chance that next child will be color blind? B) What is the chance that this last couple will have an affected daughter? (d #50x²50 (5. A man who is not bald married a non bald female whose mother is bald. A. What is the chance that the couple will have a bald son? B. What is the probability that the couple will have a bald daughter? What is the chance that the couple will have a nonbald daughter? C.
- Additional problems (Chapter 4 (Extension of Mendelian Inheritance): 1. In rabbits, coloration of the fur depends on alleles of the gene c. From information given in the chapter, what phenotypes and proportions would be expected from the following crosses: a) CC X cc b) Cc x Cc c) Cc x Ccch d) cc x cc 2. From the information given in the chapter about the ABO blood types, what phenotypes and ratios are expected from the following matings: a) type AB x type O b) Type AB x type B individual whose mother is type O c) Type O x Type A individual whose father is type O d) Type Ox type O 3. A woman with type AB blood type gave birth to a baby with type B blood. Two different men claim to be the father. One has type A blood and the other type B blood. Can the genetic evidence decide in favor of either? 4. You have been studying a trait that seems to be present in every generation within a particular family. Further, you have observed that every affected offspring has at least affected parent…Explain why absence of agglutination in A and B does not fully conclude type O phenotype.Marfan syndrome is inherited in an autosomaldominant pattern. Which of the following is true?a. Female offspring are more likely to be carriers ofthe disease.b. Male offspring are more likely to inherit thedisease.c. Male and female offspring have the samelikelihood of inheriting the disease.d. Female offspring are more likely to inherit thedisease.
- Females with a disease exactly mimicking X-linked agammaglobulinemia (XLA) have been found. Explain how this might happen?The XG locus on the human X chromosome has twoalleles, XG+ and XG. The XG+ allele causes the presence of the Xg surface antigen on red blood cells,while the recessive XG allele does not allow antigento appear. The XG locus is 10 m.u. from the STSlocus. The STS+ allele produces normal activity ofthe enzyme steroid sulfatase, while the recessive STSallele results in the lack of steroid sulfatase activityand the disease ichthyosis (scaly skin). A man withichthyosis and no Xg antigen has a normal daughterwith Xg antigen. This daughter is expecting a child.a. If the child is a son, what is the probability he willlack Xg antigen and have ichthyosis?b. What is the probability that a son would have boththe antigen and ichthyosis?c. If the child is a son with ichthyosis, what is theprobability he will have Xg antigen?In 1952, an article in the British Medical Journalreported interesting differences in the behavior ofblood plasma obtained from several people who suffered from X-linked recessive hemophilia. Whenmixed together, the cell-free blood plasma from certain combinations of individuals could form clots inthe test tube. For example, the following table showswhether clots could form (+) or not (−) in variouscombinations of plasma from four people withhemophilia:1 and 1 − 2 and 3 +1 and 2 − 2 and 4 +1 and 3 + 3 and 3 −1 and 4 + 3 and 4 −2 and 2 − 4 and 4 −What do these data tell you about the inheritance ofhemophilia in these individuals? Do these data allowyou to exclude any models for the biochemical pathway governing blood clotting?
- A boy with Klinefelter syndrome (47,XXY) is born to a motherwho is phenotypically normal and a father who has the X-linkedskin condition called anhidrotic ectodermal dysplasia. The mother’sskin is completely normal with no signs of the skin abnormality.In contrast, her son has patches of normal skin and patchesof abnormal skin. Question: Which parent contributed the abnormal gamete?2. Hemophilia is an X linked recessive trait. There is a woman who is a carrier for hemophilia and marries a man with hemophilia. a) Complete the Punnett Square (it is a google drawing so you will have to double click it to go to the drawing and type in and around the square. Hold the CONTROL (or Command) button and press the PERIOD button to write a superscript/exponent.) b) What are the possible genotypes of the children? c) Could any of their children have hemophilia? If so, would the child be male or female? Explain your reasoning.Given that I12 has cystic fibrosis, what is the chance that II18 will be a carrier of the CF allele? Please explain. Please note that I17 is FF. I 1| 2 II 1 2 3 4 5 7 III 1 2 3 4 6 7 8 9